76197

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2478532..2479363 Replicon chromosome
Accession NZ_CP021179
Organism Escherichia coli strain 81009

Toxin (Protein)


Gene name yeeV Uniprot ID A0A066T988
Locus tag DNNLJILF_RS12305 Protein ID WP_000854815.1
Coordinates 2478532..2478906 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A061Y7A8
Locus tag DNNLJILF_RS12310 Protein ID WP_001280918.1
Coordinates 2478995..2479363 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DNNLJILF_RS12270 2473928..2475094 + 1167 WP_001296209.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
DNNLJILF_RS12275 2475213..2475686 + 474 WP_001105368.1 DNA gyrase inhibitor SbmC -
DNNLJILF_RS12280 2475884..2476942 + 1059 WP_001200889.1 FUSC family protein -
DNNLJILF_RS12285 2477114..2477443 + 330 WP_000450409.1 DUF496 family protein -
DNNLJILF_RS12290 2477544..2477726 - 183 WP_001296208.1 hypothetical protein -
DNNLJILF_RS12295 2477780..2477926 + 147 Protein_2254 transposase domain-containing protein -
DNNLJILF_RS27440 2478215..2478328 - 114 WP_001161660.1 DUF957 domain-containing protein -
DNNLJILF_RS12300 2478341..2478535 - 195 WP_000988600.1 hypothetical protein -
DNNLJILF_RS12305 2478532..2478906 - 375 WP_000854815.1 type IV toxin-antitoxin system toxin CbtA Toxin
DNNLJILF_RS12310 2478995..2479363 - 369 WP_001280918.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
DNNLJILF_RS12315 2479379..2480023 - 645 WP_000086752.1 hypothetical protein -
DNNLJILF_RS12320 2480042..2480263 - 222 WP_000692345.1 DUF987 domain-containing protein -
DNNLJILF_RS12325 2480326..2480802 - 477 WP_001186200.1 RadC family protein -
DNNLJILF_RS12330 2480818..2481291 - 474 WP_001542276.1 antirestriction protein -
DNNLJILF_RS12335 2481385..2481630 - 246 WP_001164966.1 hypothetical protein -
DNNLJILF_RS12340 2481630..2482448 - 819 WP_001542275.1 DUF945 domain-containing protein -
DNNLJILF_RS12350 2482669..2483079 - 411 WP_000846703.1 hypothetical protein -
DNNLJILF_RS12355 2483095..2483445 - 351 Protein_2266 hypothetical protein -
DNNLJILF_RS12360 2483528..2484274 - 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13829.83 Da        Isoelectric Point: 7.1326

>T76197 WP_000854815.1 NZ_CP021179:c2478906-2478532 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T76197 NZ_CP021179:c2478906-2478532 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.70 Da        Isoelectric Point: 6.4767

>AT76197 WP_001280918.1 NZ_CP021179:c2479363-2478995 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT76197 NZ_CP021179:c2479363-2478995 [Escherichia coli]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A066T988

Antitoxin

Source ID Structure
AlphaFold DB A0A061Y7A8

References