Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 821092..821568 Replicon chromosome
Accession NZ_CP021178
Organism Staphylococcus aureus subsp. aureus ST398 strain 2012-3

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CAC37_RS03885 Protein ID WP_000052076.1
Coordinates 821092..821280 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CAC37_RS03890 Protein ID WP_001059690.1
Coordinates 821308..821568 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CAC37_RS03855 (817121) 817121..817603 + 483 WP_000824489.1 hypothetical protein -
CAC37_RS03860 (817944) 817944..818630 + 687 WP_001574556.1 thermonuclease family protein -
CAC37_RS03865 (818987) 818987..819187 + 201 WP_001059082.1 cold-shock protein -
CAC37_RS03870 (819684) 819684..819902 - 219 WP_000005881.1 hypothetical protein -
CAC37_RS03875 (819963) 819963..820247 - 285 WP_001004403.1 hypothetical protein -
CAC37_RS03880 (820335) 820335..820904 - 570 WP_001106655.1 lipoprotein N-acylation protein LnsA -
CAC37_RS03885 (821092) 821092..821280 - 189 WP_000052076.1 hypothetical protein Toxin
CAC37_RS03890 (821308) 821308..821568 - 261 WP_001059690.1 hypothetical protein Antitoxin
CAC37_RS03895 (821910) 821910..822113 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CAC37_RS03900 (822110) 822110..822346 - 237 WP_000368687.1 hypothetical protein -
CAC37_RS03905 (822571) 822571..823152 + 582 WP_001140696.1 histidine phosphatase family protein -
CAC37_RS03910 (823225) 823225..823842 - 618 WP_000255562.1 LysE/ArgO family amino acid transporter -
CAC37_RS03915 (823991) 823991..824485 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
CAC37_RS03920 (824884) 824884..825306 - 423 WP_000974452.1 organic hydroperoxide resistance protein -
CAC37_RS03925 (825454) 825454..826170 + 717 WP_000150026.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T76178 WP_000052076.1 NZ_CP021178:c821280-821092 [Staphylococcus aureus subsp. aureus ST398]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T76178 NZ_CP021178:c821280-821092 [Staphylococcus aureus subsp. aureus ST398]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT76178 WP_001059690.1 NZ_CP021178:c821568-821308 [Staphylococcus aureus subsp. aureus ST398]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT76178 NZ_CP021178:c821568-821308 [Staphylococcus aureus subsp. aureus ST398]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References