Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | TsxAB/MqsA(antitoxin) |
Location | 12875..13368 | Replicon | plasmid p5CRE51-MCR-1 |
Accession | NZ_CP021176 | ||
Organism | Escherichia coli strain 5CRE51 |
Toxin (Protein)
Gene name | TsxA | Uniprot ID | U9Y9W8 |
Locus tag | CA593_RS26280 | Protein ID | WP_001230709.1 |
Coordinates | 12875..13129 (+) | Length | 85 a.a. |
Antitoxin (Protein)
Gene name | TsxB | Uniprot ID | U9Y4R8 |
Locus tag | CA593_RS26285 | Protein ID | WP_000151456.1 |
Coordinates | 13126..13368 (+) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CA593_RS26240 | 8450..8611 | + | 162 | WP_001366886.1 | type I toxin-antitoxin system Hok family toxin | - |
CA593_RS26245 | 8761..9357 | + | 597 | WP_000125165.1 | hypothetical protein | - |
CA593_RS28175 | 9375..9659 | - | 285 | WP_001162371.1 | hypothetical protein | - |
CA593_RS26255 | 9733..10398 | - | 666 | WP_000532149.1 | P-loop NTPase | - |
CA593_RS26265 | 10987..11316 | + | 330 | WP_001542022.1 | hypothetical protein | - |
CA593_RS26270 | 11717..12232 | + | 516 | WP_001025393.1 | J domain-containing protein | - |
CA593_RS26275 | 12336..12878 | + | 543 | WP_001083904.1 | hypothetical protein | - |
CA593_RS26280 | 12875..13129 | + | 255 | WP_001230709.1 | hypothetical protein | Toxin |
CA593_RS26285 | 13126..13368 | + | 243 | WP_000151456.1 | hypothetical protein | Antitoxin |
CA593_RS26295 | 13939..14232 | + | 294 | WP_000673428.1 | hypothetical protein | - |
CA593_RS26300 | 14721..14969 | + | 249 | WP_000513532.1 | type II toxin-antitoxin system HicA family toxin | - |
CA593_RS26305 | 14966..15313 | + | 348 | WP_000681609.1 | type II toxin-antitoxin system HicB family antitoxin | - |
CA593_RS26310 | 15401..15583 | - | 183 | WP_001428470.1 | hypothetical protein | - |
CA593_RS26315 | 16085..16384 | + | 300 | WP_034169410.1 | type II toxin-antitoxin system HicB family antitoxin | - |
CA593_RS26320 | 16644..16970 | - | 327 | WP_000206697.1 | hypothetical protein | - |
CA593_RS26325 | 16972..17412 | - | 441 | WP_023223352.1 | hypothetical protein | - |
CA593_RS26330 | 17432..18139 | - | 708 | WP_000108794.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Mobilizable plasmid | mcr-1.1 | - | 1..60961 | 60961 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 9942.47 Da Isoelectric Point: 10.1206
>T76175 WP_001230709.1 NZ_CP021176:12875-13129 [Escherichia coli]
MRKNKGRLTYYLEVIDKKYHFVKKISSYSKEFTDGKTKRTKRTLSELVFNESEVEAIDFTKNGLRPVDKNILLTMVKEYK
ESDA
MRKNKGRLTYYLEVIDKKYHFVKKISSYSKEFTDGKTKRTKRTLSELVFNESEVEAIDFTKNGLRPVDKNILLTMVKEYK
ESDA
Download Length: 255 bp
>T76175 NZ_CP021176:12875-13129 [Escherichia coli]
ATGAGAAAAAACAAAGGGCGATTGACTTATTATCTTGAAGTGATTGATAAAAAATACCATTTTGTAAAAAAAATAAGCAG
TTATTCAAAGGAGTTCACTGACGGAAAAACAAAAAGAACAAAGAGAACGTTAAGTGAGCTGGTTTTTAATGAAAGTGAGG
TCGAGGCAATAGACTTTACAAAAAATGGTTTAAGACCTGTTGATAAGAATATTCTCTTAACTATGGTGAAAGAATATAAG
GAGAGTGATGCATGA
ATGAGAAAAAACAAAGGGCGATTGACTTATTATCTTGAAGTGATTGATAAAAAATACCATTTTGTAAAAAAAATAAGCAG
TTATTCAAAGGAGTTCACTGACGGAAAAACAAAAAGAACAAAGAGAACGTTAAGTGAGCTGGTTTTTAATGAAAGTGAGG
TCGAGGCAATAGACTTTACAAAAAATGGTTTAAGACCTGTTGATAAGAATATTCTCTTAACTATGGTGAAAGAATATAAG
GAGAGTGATGCATGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9136.45 Da Isoelectric Point: 7.2775
>AT76175 WP_000151456.1 NZ_CP021176:13126-13368 [Escherichia coli]
MTIENTPENIKKLRKKIGLTQTECGEIFGVGLSTWQKKEAKTHNQLNLSKGEFEYLLLLAGEHPEYVLHKKAESRSPEEP
MTIENTPENIKKLRKKIGLTQTECGEIFGVGLSTWQKKEAKTHNQLNLSKGEFEYLLLLAGEHPEYVLHKKAESRSPEEP
Download Length: 243 bp
>AT76175 NZ_CP021176:13126-13368 [Escherichia coli]
ATGACTATTGAAAATACACCGGAAAACATAAAGAAATTACGAAAAAAAATTGGCCTTACCCAGACAGAGTGCGGTGAGAT
TTTTGGCGTAGGCTTAAGTACATGGCAGAAAAAAGAAGCTAAAACCCACAACCAGCTTAATTTATCGAAAGGTGAATTTG
AGTACCTGTTATTACTTGCAGGGGAGCACCCTGAATACGTCCTGCATAAAAAAGCTGAATCCCGCTCACCGGAGGAACCG
TGA
ATGACTATTGAAAATACACCGGAAAACATAAAGAAATTACGAAAAAAAATTGGCCTTACCCAGACAGAGTGCGGTGAGAT
TTTTGGCGTAGGCTTAAGTACATGGCAGAAAAAAGAAGCTAAAACCCACAACCAGCTTAATTTATCGAAAGGTGAATTTG
AGTACCTGTTATTACTTGCAGGGGAGCACCCTGAATACGTCCTGCATAAAAAAGCTGAATCCCGCTCACCGGAGGAACCG
TGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3G9H8F0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3G9GNF5 |