Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4680919..4681714 Replicon chromosome
Accession NZ_CP021175
Organism Escherichia coli strain 5CRE51

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag CA593_RS24265 Protein ID WP_000854914.1
Coordinates 4680919..4681293 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7UP42
Locus tag CA593_RS24270 Protein ID WP_001280955.1
Coordinates 4681340..4681714 (-) Length 125 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA593_RS24230 4677597..4678301 + 705 WP_001241678.1 leucyl/phenylalanyl-tRNA--protein transferase -
CA593_RS24240 4678586..4678804 + 219 WP_001040187.1 translation initiation factor IF-1 -
CA593_RS24250 4679295..4680137 - 843 WP_001280481.1 DUF4942 domain-containing protein -
CA593_RS24255 4680222..4680419 - 198 WP_032278113.1 DUF957 domain-containing protein -
CA593_RS24260 4680431..4680922 - 492 WP_000976857.1 hypothetical protein -
CA593_RS24265 4680919..4681293 - 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
CA593_RS24270 4681340..4681714 - 375 WP_001280955.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CA593_RS24280 4681877..4682098 - 222 WP_001220314.1 DUF987 domain-containing protein -
CA593_RS24285 4682161..4682637 - 477 WP_001186738.1 RadC family protein -
CA593_RS24290 4682653..4683138 - 486 WP_000214398.1 antirestriction protein -
CA593_RS24295 4683229..4684047 - 819 WP_001234682.1 DUF945 domain-containing protein -
CA593_RS24310 4684387..4685457 - 1071 WP_000102669.1 patatin-like phospholipase family protein -
CA593_RS24315 4685454..4686359 - 906 WP_023149949.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T76174 WP_000854914.1 NZ_CP021175:c4681293-4680919 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T76174 NZ_CP021175:c4681293-4680919 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATATGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13767.59 Da        Isoelectric Point: 6.6248

>AT76174 WP_001280955.1 NZ_CP021175:c4681714-4681340 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT76174 NZ_CP021175:c4681714-4681340 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5


Antitoxin

Source ID Structure
AlphaFold DB A0A7U9P0D0

References