Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2369408..2370062 Replicon chromosome
Accession NZ_CP021175
Organism Escherichia coli strain 5CRE51

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag CA593_RS12340 Protein ID WP_000244781.1
Coordinates 2369655..2370062 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag CA593_RS12335 Protein ID WP_000354046.1
Coordinates 2369408..2369674 (+) Length 89 a.a.

Genomic Context

CA593_RS12320CA593_RS12325CA593_RS12335CA593_RS12340CA593_RS12350CA593_RS12355CA593_RS12360CA593_RS12315CA593_RS12330CA593_RS12345
Location: 2366974..2367285 (312 bp)
Type: Others
Protein ID: WP_001182949.1
Location: 2367449..2368108 (660 bp)
Type: Others
Protein ID: WP_000250269.1
Location: 2369408..2369674 (267 bp)
Type: Antitoxin
Protein ID: WP_000354046.1
Location: 2369655..2370062 (408 bp)
Type: Toxin
Protein ID: WP_000244781.1
Location: 2370735..2371631 (897 bp)
Type: Others
Protein ID: WP_000806638.1
Location: 2371656..2372366 (711 bp)
Type: Others
Protein ID: WP_001521231.1
Location: 2372372..2374105 (1734 bp)
Type: Others
Protein ID: WP_021523238.1
Location: 2365496..2366929 (1434 bp)
Type: Others
Protein ID: WP_001521235.1
Location: 2368185..2369165 (981 bp)
Type: Others
Protein ID: WP_000886050.1
Location: 2370102..2370623 (522 bp)
Type: Others
Protein ID: WP_001521233.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CA593_RS123152365496..2366929-1434WP_001521235.16-phospho-beta-glucosidase BglA-
CA593_RS123202366974..2367285+312WP_001182949.1N(4)-acetylcytidine aminohydrolase-
CA593_RS123252367449..2368108+660WP_000250269.1hemolysin III family protein-
CA593_RS123302368185..2369165-981WP_000886050.1tRNA-modifying protein YgfZ-
CA593_RS123352369408..2369674+267WP_000354046.1FAD assembly factor SdhEAntitoxin
CA593_RS123402369655..2370062+408WP_000244781.1protein YgfXToxin
CA593_RS123452370102..2370623-522WP_001521233.1flavodoxin FldB-
CA593_RS123502370735..2371631+897WP_000806638.1site-specific tyrosine recombinase XerD-
CA593_RS123552371656..2372366+711WP_001521231.1bifunctional protein-disulfide isomerase/oxidoreductase DsbC-
CA593_RS123602372372..2374105+1734WP_021523238.1single-stranded-DNA-specific exonuclease RecJ-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T76159 WP_000244781.1 NZ_CP021175:2369655-2370062 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T76159 NZ_CP021175:2369655-2370062 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATCTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT76159 WP_000354046.1 NZ_CP021175:2369408-2369674 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT76159 NZ_CP021175:2369408-2369674 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAGTGTGACGATCCCGATC
TGTTTAACTGGCTGATGAACCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBS1PAM6

Antitoxin

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Source
ID
Structure
PDB6B58
PDB1X6I
PDB1X6J
PDB6C12
AlphaFold DBA0A7U9QD57

References