Detailed information of TA system TA076137

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1899378..1900154
• Replicon: chromosome
• Accession: NZ_CP021171
• Organism: Staphylococcus aureus strain CHU15-056

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: B5M25_RS09605
• Protein ID: WP_000031106.1
• Coordinates: 1899378..1899530 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: B5M25_RS09610
• Protein ID: WP_001251224.1
• Coordinates: 1899555..1900154 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B5M25_RS09590	1895580..1896401	+	822	WP_000669376.1	RluA family pseudouridine synthase	-
B5M25_RS09595	1896854..1898239	-	1386	WP_000116228.1	class II fumarate hydratase	-
B5M25_RS09600	1898435..1898830	-	396	WP_000901023.1	hypothetical protein	-
B5M25_RS09605	1899378..1899530	-	153	WP_000031106.1	hypothetical protein	Toxin
B5M25_RS09610	1899555..1900154	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
B5M25_RS09615	1900313..1900783	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
B5M25_RS09620	1900788..1901915	-	1128	WP_000379980.1	tRNA epoxyqueuosine(34) reductase QueG	-
B5M25_RS09625	1902066..1902788	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
B5M25_RS09630	1902781..1904238	-	1458	WP_000649908.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5996.38 Da
• Isoelectric Point: 3.8962

>T76137 WP_000031106.1 NZ_CP021171:c1899530-1899378 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNFEEDSQ

Nucleotide

• Length: 153 bp

>T76137 NZ_CP021171:c1899530-1899378 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTTTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT76137 WP_001251224.1 NZ_CP021171:c1900154-1899555 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT76137 NZ_CP021171:c1900154-1899555 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Structures

Antitoxin

• AlphaFold DB: W8U4V4