Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 824740..825217 Replicon chromosome
Accession NZ_CP021171
Organism Staphylococcus aureus strain CHU15-056

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag B5M25_RS04125 Protein ID WP_000052076.1
Coordinates 824740..824928 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag B5M25_RS04130 Protein ID WP_001059690.1
Coordinates 824957..825217 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B5M25_RS04095 820734..821255 + 522 WP_000824482.1 hypothetical protein -
B5M25_RS04100 821596..822282 + 687 WP_000141557.1 thermonuclease family protein -
B5M25_RS04105 822639..822839 + 201 WP_001059082.1 cold-shock protein -
B5M25_RS04110 823331..823549 - 219 WP_000005886.1 hypothetical protein -
B5M25_RS04115 823611..823895 - 285 WP_001004399.1 hypothetical protein -
B5M25_RS04120 823983..824552 - 570 WP_001106654.1 hypothetical protein -
B5M25_RS04125 824740..824928 - 189 WP_000052076.1 hypothetical protein Toxin
B5M25_RS04130 824957..825217 - 261 WP_001059690.1 hypothetical protein Antitoxin
B5M25_RS04135 825558..825761 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
B5M25_RS04140 825758..825994 - 237 WP_000349581.1 hypothetical protein -
B5M25_RS04145 826219..826800 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
B5M25_RS04150 826873..827490 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
B5M25_RS04155 827645..828139 - 495 WP_110228623.1 GNAT family N-acetyltransferase -
B5M25_RS04160 828538..828960 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
B5M25_RS04165 829108..829824 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(10-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-73)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T76136 WP_000052076.1 NZ_CP021171:c824928-824740 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T76136 NZ_CP021171:c824928-824740 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT76136 WP_001059690.1 NZ_CP021171:c825217-824957 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT76136 NZ_CP021171:c825217-824957 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References