Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3801653..3802310 Replicon chromosome
Accession NZ_CP021167
Organism Enterobacter hormaechei strain 388

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag CAL61_RS18480 Protein ID WP_022649305.1
Coordinates 3801653..3802063 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag CAL61_RS18485 Protein ID WP_003863437.1
Coordinates 3802044..3802310 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CAL61_RS18460 3797651..3799384 - 1734 WP_059370853.1 single-stranded-DNA-specific exonuclease RecJ -
CAL61_RS18465 3799390..3800103 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CAL61_RS18470 3800132..3801028 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
CAL61_RS18475 3801130..3801651 + 522 WP_003863440.1 flavodoxin FldB -
CAL61_RS18480 3801653..3802063 - 411 WP_022649305.1 protein YgfX Toxin
CAL61_RS18485 3802044..3802310 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
CAL61_RS18490 3802605..3803585 + 981 WP_003863435.1 tRNA-modifying protein YgfZ -
CAL61_RS18495 3803670..3804329 - 660 WP_003863433.1 hemolysin III family protein -
CAL61_RS18500 3804596..3805327 + 732 WP_003863431.1 MurR/RpiR family transcriptional regulator -
CAL61_RS18505 3805444..3806877 + 1434 WP_003863430.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T76123 WP_022649305.1 NZ_CP021167:c3802063-3801653 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T76123 NZ_CP021167:c3802063-3801653 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTGGTGTTTGATAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATGATAGGGACGCCGTGGATGCTCAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGACAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGGGATCTGCGTCGGCTAATCGTGCAACAGCCGA
CGCAGGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT76123 WP_003863437.1 NZ_CP021167:c3802310-3802044 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT76123 NZ_CP021167:c3802310-3802044 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References