Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1094973..1095593 Replicon chromosome
Accession NZ_CP021167
Organism Enterobacter hormaechei strain 388

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag CAL61_RS05205 Protein ID WP_015571250.1
Coordinates 1094973..1095191 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag CAL61_RS05210 Protein ID WP_006809850.1
Coordinates 1095219..1095593 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CAL61_RS05175 1090985..1091245 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
CAL61_RS05180 1091248..1091388 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
CAL61_RS05185 1091385..1092095 - 711 WP_022650493.1 GNAT family N-acetyltransferase -
CAL61_RS05190 1092197..1093657 + 1461 WP_110108171.1 PLP-dependent aminotransferase family protein -
CAL61_RS05195 1093629..1094096 - 468 WP_022650495.1 hypothetical protein -
CAL61_RS05200 1094213..1094764 - 552 WP_110108172.1 maltose O-acetyltransferase -
CAL61_RS05205 1094973..1095191 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
CAL61_RS05210 1095219..1095593 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
CAL61_RS05215 1096104..1099250 - 3147 WP_022650497.1 multidrug efflux RND transporter permease subunit -
CAL61_RS05220 1099273..1100466 - 1194 WP_110108173.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T76112 WP_015571250.1 NZ_CP021167:c1095191-1094973 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T76112 NZ_CP021167:c1095191-1094973 [Enterobacter hormaechei]
ATGTCTGATAAACCATTAACAAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACCCTCGAACGTGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTGGCTGAAC
TAACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTATGGAAATTTGTTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT76112 WP_006809850.1 NZ_CP021167:c1095593-1095219 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT76112 NZ_CP021167:c1095593-1095219 [Enterobacter hormaechei]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTTAACGAGCTGATCGAGC
ATATCGCCACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACTAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References