Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4638587..4639103 Replicon chromosome
Accession NZ_CP021165
Organism Klebsiella pneumoniae strain 203

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag BH367_RS23200 Protein ID WP_002886902.1
Coordinates 4638587..4638871 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag BH367_RS23205 Protein ID WP_002886901.1
Coordinates 4638861..4639103 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BH367_RS23180 4634003..4634311 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
BH367_RS28115 4634396..4634569 + 174 WP_032408826.1 hypothetical protein -
BH367_RS23185 4634572..4635315 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
BH367_RS23190 4635672..4637810 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
BH367_RS23195 4638119..4638583 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
BH367_RS23200 4638587..4638871 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BH367_RS23205 4638861..4639103 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BH367_RS23210 4639181..4641091 - 1911 WP_009486549.1 BglG family transcription antiterminator -
BH367_RS23215 4641114..4642268 - 1155 WP_009309312.1 lactonase family protein -
BH367_RS23220 4642335..4643075 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T76106 WP_002886902.1 NZ_CP021165:c4638871-4638587 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T76106 NZ_CP021165:c4638871-4638587 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT76106 WP_002886901.1 NZ_CP021165:c4639103-4638861 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT76106 NZ_CP021165:c4639103-4638861 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References