Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 815431..816088 Replicon chromosome
Accession NZ_CP021165
Organism Klebsiella pneumoniae strain 203

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag BH367_RS04205 Protein ID WP_002916310.1
Coordinates 815678..816088 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag BH367_RS04200 Protein ID WP_002916312.1
Coordinates 815431..815697 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BH367_RS04175 810639..812072 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
BH367_RS04180 812191..812919 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
BH367_RS04185 812969..813280 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
BH367_RS04190 813444..814103 + 660 WP_002916317.1 hemolysin III family protein -
BH367_RS04195 814202..815185 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
BH367_RS04200 815431..815697 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
BH367_RS04205 815678..816088 + 411 WP_002916310.1 protein YgfX Toxin
BH367_RS04210 816095..816616 - 522 WP_004144730.1 flavodoxin FldB -
BH367_RS04215 816717..817613 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
BH367_RS04220 817636..818349 + 714 WP_071081169.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
BH367_RS04225 818355..820088 + 1734 WP_071081170.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T76094 WP_002916310.1 NZ_CP021165:815678-816088 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T76094 NZ_CP021165:815678-816088 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT76094 WP_002916312.1 NZ_CP021165:815431-815697 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT76094 NZ_CP021165:815431-815697 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References