Detailed information of TA system TA076090

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4141641..4142310
• Replicon: chromosome
• Accession: NZ_CP021164
• Organism: Serratia marcescens strain 332

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: B1A42_RS20170
• Protein ID: WP_049199217.1
• Coordinates: 4141641..4142063 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A8B4GS04
• Locus tag: B1A42_RS20175
• Protein ID: WP_019455657.1
• Coordinates: 4142044..4142310 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B1A42_RS20150	4137574..4139307	-	1734	WP_049199214.1	single-stranded-DNA-specific exonuclease RecJ	-
B1A42_RS20155	4139314..4140030	-	717	WP_038871236.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
B1A42_RS20160	4140057..4140956	-	900	WP_049199323.1	site-specific tyrosine recombinase XerD	-
B1A42_RS20165	4141063..4141581	+	519	WP_038871234.1	flavodoxin FldB	-
B1A42_RS20170	4141641..4142063	-	423	WP_049199217.1	protein YgfX	Toxin
B1A42_RS20175	4142044..4142310	-	267	WP_019455657.1	FAD assembly factor SdhE	Antitoxin
B1A42_RS20180	4142631..4143623	+	993	WP_049273460.1	tRNA-modifying protein YgfZ	-
B1A42_RS20185	4143662..4144159	-	498	WP_049199221.1	DUF2165 domain-containing protein	-
B1A42_RS20190	4144308..4144982	-	675	WP_033639467.1	hemolysin III family protein	-
B1A42_RS20195	4145166..4145774	+	609	WP_025304127.1	HD domain-containing protein	-
B1A42_RS20200	4145807..4146733	-	927	WP_049199223.1	ribokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16411.48 Da
• Isoelectric Point: 10.3761

>T76090 WP_049199217.1 NZ_CP021164:c4142063-4141641 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGLGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLQPTEGKKRRRLWLASDCMSKEEWCHLRQLLLYPPAGDGEPE

Nucleotide

• Length: 423 bp

>T76090 NZ_CP021164:c4142063-4141641 [Serratia marcescens]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACCCAGCTGTTTTCCCTGTTGACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGCTTGGGCCCGCTCTGGCTGGTGCTGTTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCTGCGGTGCAGGGCGAGCTGCGGCTGTTGGCGGACCGGCGCTTCAGCTGGCACGGCCGC
GAGTGGCGGCTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGCTGCTGACGCTGCAGCCGACGGAGGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCAGACTGCATGAGCAAAGAGGAGTGGTGCCACCTGCGGCAGCTGTTGCTGTATCCGCCGG
CGGGTGACGGCGAACCAGAGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10417.91 Da
• Isoelectric Point: 4.7921

>AT76090 WP_019455657.1 NZ_CP021164:c4142310-4142044 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT76090 NZ_CP021164:c4142310-4142044 [Serratia marcescens]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGTCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCGTTGTTCATCCGCCTGCTGGAGTGCGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACAGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GS04