Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2328469..2329208 Replicon chromosome
Accession NZ_CP021162
Organism Enterobacter hormaechei strain 234

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag BET69_RS11430 Protein ID WP_047055520.1
Coordinates 2328469..2328954 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A927HKN6
Locus tag BET69_RS11435 Protein ID WP_045336276.1
Coordinates 2328942..2329208 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BET69_RS11410 2324623..2325381 - 759 WP_023314159.1 trans-aconitate 2-methyltransferase -
BET69_RS11415 2325466..2326050 - 585 WP_045336272.1 GDP-mannose pyrophosphatase -
BET69_RS11420 2326137..2326895 + 759 WP_045336273.1 DeoR/GlpR family DNA-binding transcription regulator -
BET69_RS11425 2327000..2328292 + 1293 WP_050870612.1 glycoside hydrolase -
BET69_RS11430 2328469..2328954 - 486 WP_047055520.1 GNAT family N-acetyltransferase Toxin
BET69_RS11435 2328942..2329208 - 267 WP_045336276.1 DUF1778 domain-containing protein Antitoxin
BET69_RS11440 2329272..2330201 - 930 WP_110108391.1 LysR family transcriptional regulator -
BET69_RS11445 2330331..2331719 + 1389 WP_110108392.1 MFS transporter -
BET69_RS11450 2331741..2332736 - 996 WP_032658432.1 DUF2891 domain-containing protein -
BET69_RS11455 2332746..2333732 - 987 WP_003857123.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(80-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T76064 WP_047055520.1 NZ_CP021162:c2328954-2328469 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLGEFVSGEAVLDEWLKQRGLKNQALGAARTFVICKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T76064 NZ_CP021162:c2328954-2328469 [Enterobacter hormaechei]
GTGGGGCGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGGGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCATTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCACTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATACTTGCCCGTCTGGCTGTTGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGGGTAGCTGAGAATATTGGGGTGCGGGCGATCATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCCTCGCAGACTCAGGAACGGACACTGTTTCTCCGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10032.46 Da        Isoelectric Point: 4.4857

>AT76064 WP_045336276.1 NZ_CP021162:c2329208-2328942 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWGV

Download         Length: 267 bp

>AT76064 NZ_CP021162:c2329208-2328942 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGTACAGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTTATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCGCAGTGGGGCGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References