Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2990614..2992442 Replicon chromosome
Accession NZ_CP021145
Organism Vibrio campbellii strain LA16-V1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CAY59_RS14230 Protein ID WP_062851242.1
Coordinates 2990614..2991975 (+) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CAY59_RS14235 Protein ID WP_029786578.1
Coordinates 2991960..2992442 (+) Length 161 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CAY59_RS14215 2988338..2988724 + 387 WP_062851243.1 hypothetical protein -
CAY59_RS14225 2989341..2990123 + 783 WP_031428771.1 metallophosphoesterase -
CAY59_RS14230 2990614..2991975 + 1362 WP_062851242.1 type II toxin-antitoxin system HipA family toxin Toxin
CAY59_RS14235 2991960..2992442 + 483 WP_029786578.1 helix-turn-helix domain-containing protein Antitoxin
CAY59_RS14240 2992792..2993685 + 894 WP_086369674.1 LysR family transcriptional regulator -
CAY59_RS14245 2993785..2995827 + 2043 WP_086369675.1 FUSC family protein -
CAY59_RS14250 2995973..2996548 + 576 WP_050914360.1 DedA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2945675..3004137 58462


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-385)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-139)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51397.15 Da        Isoelectric Point: 4.8182

>T76053 WP_062851242.1 NZ_CP021145:2990614-2991975 [Vibrio campbellii]
MEELTVQAFIRGEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHHDKDDFHAVSLNHPVSFFFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIEQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPVYDFAPMKADPEGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEVLLQELEVTASKCIDLKQRLALRGVPEQILEMPAVGLNHISEKLTKWGLL

Download         Length: 1362 bp

>T76053 NZ_CP021145:2990614-2991975 [Vibrio campbellii]
ATGGAAGAACTAACCGTACAAGCTTTTATCAGAGGTGAATGGATAGATATTGGTATCATCTCATTCCCTAAAAGTAGCCA
ACATAATTTCCGAGTGACTGAACTCAACTACCTCAGCGACTATGCGCTAGAACATCACGATAAAGATGACTTTCACGCTG
TTTCACTAAACCACCCTGTCTCATTCTTTTTTGATGACATGGGTAAACCTGGATGGTTAAAGTTTCTAGACGATATTATG
CCTAGTGGCGCTAGTAGACGATACTGGGTCAAACACCTAGATATTGAAGACCTTAGTTCTGATGAACAAGACTATGTTTT
GCTCAAGTTTGGCACAATGTCGCCTATCGGTAACTTAAGAATAAAAGACTCTCTTCCTGAGCGCTACGAAGTAGCAGACA
ACCTCTACTTCTCTGTTGATGATGTTAAAAATCGAGCAGGTGATTTCCTCGACTATGCACAGCAAAGAGGGGCAGCCGCA
GGTGGTGCAACAGGGGCTGGAGGTGAAGCGCCAAAACTGATCCTCCGATGTGGTTTCGATCATGGATCTGGCAGCGAAAA
AATATGGATTGACCCATACCAAGATGACAATAGCAACCACGACTTACATTACTTAGTAAAGTACCCTAGAGGCTCAAGAA
GCACCATCGACTGTAATATTCTAAGAGCTGAGTTCTACTTCTACCACGAGCTAACTGAAATGGGAGTTGAAACGATCTCC
ACCGACGGTATGCGCTTGGAGGAAGGATTAAACTACCCTTCCTTGTGGCTTCCTCGATTTGATGTTCAAATTATTGAGCA
ACAAATAGAGAGATTTGGCATGGAATCTGTGTATTCCATTTTGAACAAAGGCGCTGGGGTCACTCTTGATCACGAAACAA
CAATCCGAACTCTCATAGAAAAAATTACTGAAAGCAATATGGTTAAACACCAAGGGTATAGGTTTGATACCCAAGCTTTC
GTCATTGAATGGGTGAAGAGAGATCTACTCAACATCTTGTTTGGTAATAGTGATAACCATGGCAGAAACACTTCATTCTT
AAAAGGTGATGGAGTCATAAAGCTTGCTCCCGTTTACGACTTCGCACCAATGAAAGCTGATCCTGAAGGCATTCCAAGAA
CAACAAAATGGAAAGCCCCACTAGAGGTTGGCGGAACTTACGACTTCGTAGGAATAGCGGACACCTTATCTGATCTCGTG
CCAAAAGAAGTGTTATTACAAGAGCTAGAGGTTACTGCAAGTAAATGCATTGATTTAAAGCAGAGACTAGCATTACGAGG
AGTACCAGAACAAATCTTAGAGATGCCAGCCGTTGGACTTAATCATATATCAGAAAAGCTCACTAAATGGGGGCTACTAT
GA

Antitoxin


Download         Length: 161 a.a.        Molecular weight: 17535.05 Da        Isoelectric Point: 10.8446

>AT76053 WP_029786578.1 NZ_CP021145:2991960-2992442 [Vibrio campbellii]
MGATMNKPSNKESVQDTVARLRANRNQHQPKTGTDATHSTKERSQLNTPTRSKTSKNAKAVSAAERKTEANKIIKHLLLG
ELTQGQALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFGLKVGMLPSSPDVLKSLLIDGEAG

Download         Length: 483 bp

>AT76053 NZ_CP021145:2991960-2992442 [Vibrio campbellii]
ATGGGGGCTACTATGAATAAGCCAAGCAATAAAGAGTCCGTACAAGATACCGTTGCTCGTCTAAGAGCAAACCGAAATCA
ACATCAGCCCAAGACTGGGACGGATGCAACTCATTCGACCAAAGAACGATCGCAACTTAATACTCCGACTAGATCGAAAA
CCTCAAAAAACGCCAAAGCAGTAAGTGCAGCAGAACGCAAAACAGAGGCAAACAAAATCATCAAACACTTGTTGCTTGGA
GAGCTAACACAAGGCCAAGCGTTAAAAAGTTTACGCATTAATATACTGGGACTCAAACAGGATGTGTTCGCAAGACTTGT
AGATGTCTCAAGAAAAACACTCTCAGATATAGAGAATGATCGGGGCAGCTACAATACAGAGATTCTCAACAAGGTATTCA
AGCCATTTGGCTTAAAAGTCGGAATGCTACCGTCTTCTCCCGATGTGTTAAAATCGCTACTAATAGATGGTGAGGCTGGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References