76052

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1564001..1564560 Replicon chromosome
Accession NZ_CP021145
Organism Vibrio campbellii strain LA16-V1

Toxin (Protein)


Gene name relE Uniprot ID A0A347UR22
Locus tag CAY59_RS07745 Protein ID WP_005398411.1
Coordinates 1564001..1564279 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR21
Locus tag CAY59_RS07750 Protein ID WP_005398409.1
Coordinates 1564276..1564560 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CAY59_RS28785 1559454..1559531 + 78 Protein_1371 DUF3265 domain-containing protein -
CAY59_RS07695 1559661..1559984 - 324 WP_086369232.1 hypothetical protein -
CAY59_RS07700 1560071..1560202 + 132 WP_080339216.1 DUF3265 domain-containing protein -
CAY59_RS07705 1560225..1560914 + 690 WP_157664687.1 class I SAM-dependent methyltransferase -
CAY59_RS07710 1560927..1561052 + 126 WP_079403019.1 DUF3265 domain-containing protein -
CAY59_RS07715 1561082..1561498 + 417 WP_086369233.1 hypothetical protein -
CAY59_RS07720 1561464..1561613 + 150 WP_080765391.1 DUF3265 domain-containing protein -
CAY59_RS07725 1561662..1561988 + 327 WP_025633776.1 hypothetical protein -
CAY59_RS07730 1562135..1562731 + 597 WP_086369234.1 methyltransferase domain-containing protein -
CAY59_RS07735 1562911..1563399 + 489 WP_045397058.1 hypothetical protein -
CAY59_RS07740 1563550..1563864 + 315 WP_019277227.1 hypothetical protein -
CAY59_RS07745 1564001..1564279 - 279 WP_005398411.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
CAY59_RS07750 1564276..1564560 - 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CAY59_RS07755 1564637..1564728 + 92 Protein_1384 DUF3265 domain-containing protein -
CAY59_RS07760 1565141..1565272 + 132 WP_080544925.1 DUF3265 domain-containing protein -
CAY59_RS07765 1565320..1565754 + 435 WP_038892661.1 hypothetical protein -
CAY59_RS07770 1565780..1566749 - 970 Protein_1387 IS30-like element ISVa6 family transposase -
CAY59_RS07775 1567005..1567373 + 369 WP_017420678.1 hypothetical protein -
CAY59_RS07780 1567388..1567480 + 93 WP_005377014.1 DUF3265 domain-containing protein -
CAY59_RS07790 1567970..1568101 + 132 WP_086369840.1 DUF3265 domain-containing protein -
CAY59_RS07795 1568175..1568663 + 489 WP_045397058.1 hypothetical protein -
CAY59_RS07800 1568791..1569300 + 510 WP_086369235.1 hypothetical protein -
CAY59_RS07805 1569297..1569407 + 111 WP_080586398.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1521648..1590442 68794
- inside Integron - - 1520439..1583131 62692


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10891.57 Da        Isoelectric Point: 4.3430

>T76052 WP_005398411.1 NZ_CP021145:c1564279-1564001 [Vibrio campbellii]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T76052 NZ_CP021145:c1564279-1564001 [Vibrio campbellii]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTGATGGGTGTACAACGAGATGGCA
TCCGCGGACGATTGCTCATTATTCCTGAGATTTCGATGATTGTATCTTACTGGGTTGAGGGCGATATCATCCGTGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11069.40 Da        Isoelectric Point: 9.2167

>AT76052 WP_005398409.1 NZ_CP021145:c1564560-1564276 [Vibrio campbellii]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT76052 NZ_CP021145:c1564560-1564276 [Vibrio campbellii]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGAAC
TTTAAGTGATGCTTGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCTGTTTTCGTTGAGCACCAAACTGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR22

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR21

References