Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PsyrTA/-
Location 2974710..2976049 Replicon chromosome
Accession NZ_CP021144
Organism Shigella sonnei strain 2015AM-1099

Toxin (Protein)


Gene name PsyrT Uniprot ID -
Locus tag B9127_RS16705 Protein ID WP_001119379.1
Coordinates 2975912..2976049 (-) Length 46 a.a.

Antitoxin (Protein)


Gene name PsyrA Uniprot ID A0A656BP16
Locus tag B9127_RS16700 Protein ID WP_001053680.1
Coordinates 2974710..2975912 (-) Length 401 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B9127_RS16685 (2970317) 2970317..2972503 - 2187 WP_001283723.1 1,4-alpha-glucan branching enzyme -
B9127_RS28015 (2972661) 2972661..2972702 - 42 WP_211180509.1 protein YhgO -
B9127_RS16690 (2972776) 2972776..2973879 - 1104 WP_000799956.1 aspartate-semialdehyde dehydrogenase -
B9127_RS16695 (2974071) 2974071..2974664 + 594 WP_000991414.1 NAAT family transporter YhgN -
B9127_RS16700 (2974710) 2974710..2975912 - 1203 WP_001053680.1 DNA-processing protein DprA Antitoxin
B9127_RS16705 (2975912) 2975912..2976049 - 138 WP_001119379.1 hypothetical protein Toxin
B9127_RS16715 (2976848) 2976848..2978659 - 1812 WP_005140413.1 helicase-related protein -
B9127_RS16720 (2978800) 2978800..2980140 - 1341 WP_000210099.1 gluconate transporter -
B9127_RS16725 (2980144) 2980144..2980671 - 528 WP_000108330.1 gluconokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Phosphoribosyltransferase domain

(6-34)

Antitoxin

DNA recombination-mediator protein A

(89-292)


Sequences

Toxin        


Download         Length: 46 a.a.        Molecular weight: 4683.50 Da        Isoelectric Point: 4.3115

>T76047 WP_001119379.1 NZ_CP021144:c2976049-2975912 [Shigella sonnei]
MPGPALLVDDIVDSAWTLTVLTALLRQAGCPTVYPLALASTSVKN

Download         Length: 138 bp

>T76047 NZ_CP021144:c2976049-2975912 [Shigella sonnei]
ATGCCTGGTCCGGCGTTGCTGGTTGACGATATCGTGGATTCTGCATGGACGCTGACAGTTCTGACAGCACTGTTACGCCA
GGCAGGTTGCCCGACGGTTTATCCTCTTGCCCTTGCTTCTACCTCGGTAAAAAATTGA

Antitoxin


Download         Length: 401 a.a.        Molecular weight: 43812.21 Da        Isoelectric Point: 6.6429

>AT76047 WP_001053680.1 NZ_CP021144:c2975912-2974710 [Shigella sonnei]
MNLSANAQATLLLTSDFSRAAASEYKPLSNSEWGKFALWLKHQRISPAELLVPQPQEKLTGWSDPRISQERILGLLARGH
SLALAVDKWQRAGLWILTRGDADYPVRLKNRLRTDAPPVLFGCGNKALLQAEGMAIVGSRDAPTDDLRYTQQLAAKLAQQ
GICVISGGARGIDECAMASALEAGGTAVGVLADSLLKTSTLVKWREGLIAGNLVLISPFYPEVRFTVGNAMARNKYIYCL
AESAMVVRAGMTGGTITGAMEALKHQWLPVQVKPNQDMQSANSRLVENGASWSAEQAENVTIRLPDVPGLMYDRALRNAQ
PELFSLHEDDANYAVMPAYTPVDFYQLFVAELAILAKESISIERLASCTGLTIEQISVWLNRAEEEGRVIRLGEGHYQFR

Download         Length: 1203 bp

>AT76047 NZ_CP021144:c2975912-2974710 [Shigella sonnei]
ATGAATCTTTCAGCCAATGCACAAGCAACTCTCCTGCTAACCAGCGATTTTTCTCGCGCGGCGGCGAGTGAGTATAAACC
TCTTAGTAATAGTGAATGGGGGAAGTTTGCATTATGGCTGAAGCACCAACGTATCAGTCCCGCCGAGCTTCTGGTGCCGC
AACCGCAAGAGAAACTTACAGGCTGGAGCGATCCGCGTATTTCTCAGGAGCGTATTCTTGGCTTGCTGGCGCGTGGTCAT
AGTCTGGCGTTGGCGGTAGATAAGTGGCAACGCGCCGGTTTATGGATCTTAACCCGCGGAGATGCTGATTATCCCGTTCG
CTTGAAAAACCGATTGCGAACGGATGCACCTCCCGTTTTATTTGGCTGCGGGAATAAAGCATTACTGCAAGCGGAAGGTA
TGGCGATTGTTGGCTCGCGAGATGCTCCGACTGACGATTTGCGCTATACCCAACAACTGGCCGCGAAACTGGCCCAACAG
GGGATTTGCGTTATCTCTGGTGGTGCGCGAGGTATTGATGAATGTGCAATGGCGTCGGCACTGGAGGCCGGGGGAACTGC
CGTTGGCGTATTAGCTGATAGCTTGTTAAAAACGAGTACGTTAGTGAAATGGCGTGAAGGGCTTATAGCAGGCAACCTGG
TGTTGATTTCGCCGTTTTACCCAGAGGTACGTTTCACCGTCGGCAATGCGATGGCGCGAAATAAATATATTTATTGCCTT
GCTGAAAGCGCAATGGTTGTACGTGCGGGAATGACCGGTGGAACGATAACCGGGGCGATGGAGGCATTAAAACATCAGTG
GCTGCCTGTGCAGGTTAAACCAAATCAGGATATGCAATCAGCCAATTCACGATTAGTAGAAAATGGGGCGTCATGGAGTG
CTGAACAGGCTGAGAATGTGACGATCAGACTGCCAGACGTTCCTGGGCTGATGTATGACAGAGCACTCCGTAACGCTCAA
CCAGAACTGTTTTCGCTGCATGAAGATGACGCAAATTACGCAGTAATGCCCGCGTATACGCCTGTCGATTTTTATCAACT
CTTTGTGGCGGAACTGGCGATCCTTGCAAAGGAATCGATAAGTATTGAAAGGCTGGCGTCTTGTACTGGTTTAACCATCG
AACAAATTAGTGTGTGGCTGAACCGCGCAGAAGAAGAGGGAAGGGTTATCCGATTGGGCGAAGGTCATTATCAGTTCAGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A656BP16

References