Detailed information of TA system TA076032

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1765820..1766320
• Replicon: chromosome
• Accession: NZ_CP021140
• Organism: Eggerthella lenta strain C592

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CAB18_RS07655
• Protein ID: WP_035585267.1
• Coordinates: 1765820..1766092 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C8WHL1
• Locus tag: CAB18_RS07660
• Protein ID: WP_015760684.1
• Coordinates: 1766093..1766320 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CAB18_RS07630	1761093..1762016	+	924	WP_009608610.1	GTPase Era	-
CAB18_RS07635	1762212..1763717	+	1506	WP_086414571.1	PASTA domain-containing protein	-
CAB18_RS07640	1763723..1764493	+	771	WP_009307048.1	DNA repair protein RecO	-
CAB18_RS07645	1764532..1764783	+	252	WP_009307046.1	TIGR03905 family TSCPD domain-containing protein	-
CAB18_RS07650	1764768..1765550	-	783	WP_086414572.1	C39 family peptidase	-
CAB18_RS07655	1765820..1766092	-	273	WP_035585267.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CAB18_RS07660	1766093..1766320	-	228	WP_015760684.1	hypothetical protein	Antitoxin
CAB18_RS07665	1766455..1767558	-	1104	WP_015760683.1	Exonuclease RNase T and DNA polymerase III	-
CAB18_RS07670	1767584..1768261	-	678	WP_015760682.1	leucine-rich repeat domain-containing protein	-
CAB18_RS07675	1768527..1769225	+	699	WP_086414573.1	response regulator transcription factor	-
CAB18_RS07680	1769238..1770392	+	1155	WP_086414574.1	HAMP domain-containing histidine kinase	-
CAB18_RS07685	1770675..1770962	+	288	WP_009307039.1	30S ribosomal protein S15	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (3-69)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10150.78 Da
• Isoelectric Point: 10.2288

>T76032 WP_035585267.1 NZ_CP021140:c1766092-1765820 [Eggerthella lenta]
MGYSVELTSGAAKQLQSLDRKTLLLVSELIERLDGCENPCMLPNAKKLQGVKNGWRWRSGTYRVLGTVDGSRITIEVFKI
GHRRDVYRGL

Nucleotide

• Length: 273 bp

>T76032 NZ_CP021140:c1766092-1765820 [Eggerthella lenta]
TTGGGCTATTCGGTAGAGTTGACGAGCGGAGCGGCGAAGCAGCTGCAAAGCCTCGATCGCAAAACCCTTCTGCTGGTATC
GGAACTGATCGAGCGCCTTGACGGATGCGAGAACCCCTGCATGCTCCCCAACGCGAAGAAGCTCCAAGGGGTGAAGAACG
GTTGGCGCTGGCGTTCCGGAACGTATCGTGTTCTCGGCACAGTCGACGGTAGCCGGATAACGATCGAGGTATTCAAGATC
GGACATCGTCGAGACGTATACCGCGGCTTATAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8478.44 Da
• Isoelectric Point: 4.1068

>AT76032 WP_015760684.1 NZ_CP021140:c1766320-1766093 [Eggerthella lenta]
MAMTASAIRFEPNEKEWIAAFAEMNGSTFSAQVRQWTLERLEDELDARDLSQAIEEDDGTRISWSKVKSDLGLAI

Nucleotide

• Length: 228 bp

>AT76032 NZ_CP021140:c1766320-1766093 [Eggerthella lenta]
ATGGCGATGACGGCATCGGCTATTCGGTTCGAGCCGAATGAGAAGGAATGGATTGCAGCGTTTGCCGAGATGAACGGTTC
CACGTTTTCCGCGCAAGTGCGCCAGTGGACGCTCGAACGCCTTGAGGACGAACTTGACGCTCGGGACCTTTCGCAAGCTA
TCGAAGAAGACGATGGCACGCGTATTTCCTGGAGCAAGGTCAAGTCCGATCTCGGGCTGGCGATTTGA

Structures

Antitoxin

• AlphaFold DB: C8WHL1