Detailed information of TA system TA076026

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 252730..253409
• Replicon: plasmid pMtWR-220
• Accession: NZ_CP021131
• Organism: Meiothermus taiwanensis WR-220

Toxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MTAI_RS14975
• Protein ID: WP_027883278.1
• Coordinates: 252987..253409 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A511R2P8
• Locus tag: MTAI_RS14970
• Protein ID: WP_027883277.1
• Coordinates: 252730..252990 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTAI_RS14950	248678..249781	-	1104	WP_027888004.1	erythromycin esterase family protein	-
MTAI_RS14955	250256..251185	+	930	WP_187388631.1	hypothetical protein	-
MTAI_RS14960	251205..252242	+	1038	WP_027888002.1	hypothetical protein	-
MTAI_RS15120	252249..252551	+	303	WP_027883276.1	hypothetical protein	-
MTAI_RS14970	252730..252990	+	261	WP_027883277.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
MTAI_RS14975	252987..253409	+	423	WP_027883278.1	type II toxin-antitoxin system VapC family toxin	Toxin
MTAI_RS14980	253520..253777	+	258	WP_155915736.1	hypothetical protein	-
MTAI_RS14985	253875..254249	-	375	WP_162147916.1	ankyrin repeat domain-containing protein	-
MTAI_RS14990	255034..255243	-	210	Protein_237	ATP-binding protein	-
MTAI_RS14995	255409..255618	+	210	WP_018466043.1	helix-turn-helix domain-containing protein	-
MTAI_RS15000	255644..256081	+	438	WP_036197014.1	hypothetical protein	-
MTAI_RS15005	256078..256308	+	231	WP_027883466.1	DUF4926 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..271068	271068

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-123)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-71)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 15231.57 Da
• Isoelectric Point: 9.8234

>T76026 WP_027883278.1 NZ_CP021131:252987-253409 [Meiothermus taiwanensis WR-220]
MSYLLDTNVVSEAAKRQPDPRVTAWLKGLSVREAYLSALTLGELVQGAVRAPEPRRAVLEGWIEDLKRRFAGQILPLDTG
VMETWGALTGEALNQGRPLSPLDALLAATALRHGLTLVSRNTGHFRGLPVRLLNPWEAGA

Nucleotide

• Length: 423 bp

>T76026 NZ_CP021131:252987-253409 [Meiothermus taiwanensis WR-220]
TTGAGCTACCTGCTCGACACCAACGTGGTCTCCGAGGCGGCCAAGCGTCAGCCCGACCCCAGGGTTACGGCCTGGCTGAA
AGGGCTCTCCGTGCGGGAAGCCTACCTTTCCGCTCTCACCTTGGGCGAGCTGGTGCAGGGGGCCGTCCGCGCCCCCGAGC
CGCGCCGAGCTGTCCTGGAAGGCTGGATCGAAGACCTCAAGCGGCGCTTCGCCGGGCAGATTCTGCCCCTGGACACGGGG
GTCATGGAGACGTGGGGCGCCCTCACCGGCGAGGCCCTGAACCAGGGCCGCCCCCTTTCCCCCCTGGACGCCCTGCTGGC
GGCCACCGCCCTGCGCCACGGCCTCACCCTGGTCAGCCGCAACACCGGCCACTTCCGGGGCCTGCCCGTTCGGCTGCTCA
ACCCCTGGGAGGCGGGGGCCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9740.92 Da
• Isoelectric Point: 5.2090

>AT76026 WP_027883277.1 NZ_CP021131:252730-252990 [Meiothermus taiwanensis WR-220]
VKRSWQLQEAKARFSEVVEQALKGEAQTVTRRGRPAVVVLDWATYTRLRGEDTPLLEALRPPEPLSDEEAEALSDRSRAG
YREVGF

Nucleotide

• Length: 261 bp

>AT76026 NZ_CP021131:252730-252990 [Meiothermus taiwanensis WR-220]
GTGAAACGCAGCTGGCAGCTTCAGGAGGCCAAGGCCCGCTTCTCCGAGGTGGTGGAGCAGGCCCTGAAGGGCGAGGCCCA
GACCGTGACCCGGCGGGGCCGGCCCGCGGTGGTGGTGCTGGACTGGGCGACCTACACCCGCCTTCGCGGCGAGGATACCC
CCCTGCTCGAGGCCCTCCGCCCGCCGGAGCCCCTCTCCGACGAGGAGGCCGAGGCCCTCTCCGACCGGTCGCGCGCAGGC
TACCGGGAGGTGGGCTTTTGA

Structures

Antitoxin

• AlphaFold DB: A0A511R2P8