Detailed information of TA system TA076025

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 2543574..2544039
• Replicon: chromosome
• Accession: NZ_CP021130
• Organism: Meiothermus taiwanensis WR-220

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: A0A399DRA8
• Locus tag: MTAI_RS12555
• Protein ID: WP_027886940.1
• Coordinates: 2543574..2543843 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A399DR17
• Locus tag: MTAI_RS12560
• Protein ID: WP_027886939.1
• Coordinates: 2543827..2544039 (-)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTAI_RS12535	2538884..2539573	-	690	WP_027886944.1	1-acyl-sn-glycerol-3-phosphate acyltransferase	-
MTAI_RS12540	2539570..2540604	-	1035	WP_051349796.1	carotenoid biosynthesis protein	-
MTAI_RS12545	2540736..2541929	-	1194	WP_027886942.1	lycopene cyclase	-
MTAI_RS12550	2542010..2543542	-	1533	WP_027886941.1	NAD(P)/FAD-dependent oxidoreductase	-
MTAI_RS12555	2543574..2543843	-	270	WP_027886940.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MTAI_RS12560	2543827..2544039	-	213	WP_027886939.1	ribbon-helix-helix protein, CopG family	Antitoxin
MTAI_RS12565	2544093..2544920	-	828	WP_027886938.1	phytoene/squalene synthase family protein	-
MTAI_RS12570	2544947..2545621	-	675	WP_027886937.1	class I SAM-dependent methyltransferase	-
MTAI_RS12575	2545741..2546622	+	882	WP_027886936.1	MerR family transcriptional regulator	-
MTAI_RS12580	2546684..2547274	+	591	WP_043982676.1	cyclic nucleotide-binding domain-containing protein	-
MTAI_RS12585	2547282..2548181	+	900	WP_027886935.1	complex I NDUFA9 subunit family protein	-
MTAI_RS12590	2548228..2549034	-	807	WP_119342530.1	IS5 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2548228..2549034	806

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-88)

Antitoxin

• Relaxosome protein TraY (4-44)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10744.49 Da
• Isoelectric Point: 10.4948

>T76025 WP_027886940.1 NZ_CP021130:c2543843-2543574 [Meiothermus taiwanensis WR-220]
MGYRIEFDPRAEKELAKLDREVARRIVRFLRERVALLDDPRSLGEALHGPELGRFWKYRVGDYRLICHIQDQRITVLVLR
IGHRRDVYR

Nucleotide

• Length: 270 bp

>T76025 NZ_CP021130:c2543843-2543574 [Meiothermus taiwanensis WR-220]
TTGGGTTACAGGATTGAGTTCGACCCACGGGCCGAGAAGGAGCTGGCGAAGCTGGATCGTGAGGTGGCGCGCCGCATCGT
GCGTTTTTTGCGCGAGCGGGTGGCCTTGCTGGATGATCCCCGTAGCCTTGGGGAGGCCTTGCACGGGCCGGAGCTGGGCC
GGTTTTGGAAGTACCGGGTGGGTGATTATCGCCTGATCTGCCATATCCAGGATCAAAGAATCACTGTGCTGGTCTTGCGG
ATTGGGCATCGGCGGGATGTCTACCGCTGA

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 8266.51 Da
• Isoelectric Point: 4.8605

>AT76025 WP_027886939.1 NZ_CP021130:c2544039-2543827 [Meiothermus taiwanensis WR-220]
MLAIRLPKEIEERLEALARKTGRSKSYYVRQAILEHLDDLEDYYLAVERLEQKLPGIPLDEVERRLGLQD

Nucleotide

• Length: 213 bp

>AT76025 NZ_CP021130:c2544039-2543827 [Meiothermus taiwanensis WR-220]
ATGCTGGCTATCCGGCTGCCCAAGGAGATAGAGGAACGCCTCGAGGCCCTTGCCCGGAAAACCGGGCGCAGCAAGAGCTA
TTACGTGCGCCAGGCCATCCTGGAGCACCTCGATGACCTCGAGGACTACTATCTGGCCGTAGAGCGGCTCGAGCAGAAGT
TGCCAGGCATTCCCCTAGACGAAGTGGAGCGCCGCCTTGGGTTACAGGATTGA

Structures

Toxin

• AlphaFold DB: A0A399DRA8

Antitoxin

• AlphaFold DB: A0A399DR17