Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 8528..9189 Replicon plasmid pRetKim5c
Accession NZ_CP021127
Organism Rhizobium sp. Kim5

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KIM5_RS27165 Protein ID WP_077988926.1
Coordinates 8528..8932 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KIM5_RS27170 Protein ID WP_077988927.1
Coordinates 8929..9189 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIM5_RS27150 4000..4938 - 939 WP_077988924.1 hydrogen peroxide-inducible genes activator -
KIM5_RS27155 5083..7269 + 2187 WP_086156636.1 catalase/peroxidase HPI -
KIM5_RS27160 7721..8446 + 726 WP_077988925.1 SDR family oxidoreductase -
KIM5_RS27165 8528..8932 - 405 WP_077988926.1 type II toxin-antitoxin system VapC family toxin Toxin
KIM5_RS27170 8929..9189 - 261 WP_077988927.1 antitoxin Antitoxin
KIM5_RS27175 9271..9822 - 552 WP_009989453.1 DUF3299 domain-containing protein -
KIM5_RS27180 10266..10721 - 456 WP_077988928.1 SgcJ/EcaC family oxidoreductase -
KIM5_RS27185 10960..12039 + 1080 WP_077988929.1 sensor histidine kinase -
KIM5_RS27190 12036..12695 + 660 WP_040141498.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..655866 655866


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-126)

Antitoxin

SpoVT-AbrB domain

(8-48)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14758.91 Da        Isoelectric Point: 4.6076

>T76020 WP_077988926.1 NZ_CP021127:c8932-8528 [Rhizobium sp. Kim5]
VITHLIDTNAVIALISRKFDALLKRVVDSDEGSIGLSTIVMHELYYGAYKSAKISYNLETLRLFMADFPAVGFEREDALE
SGEIRAALAAKGTPIGPYDVLIAAQAKTRDLVLITNNVGEFRRVDGLDVEDWTI

Download         Length: 405 bp

>T76020 NZ_CP021127:c8932-8528 [Rhizobium sp. Kim5]
GTGATCACGCATCTTATCGACACCAATGCGGTGATCGCGCTGATCAGCAGGAAATTCGACGCGCTGCTGAAGCGCGTGGT
CGACAGCGACGAAGGATCGATCGGGCTTTCCACCATCGTGATGCATGAGCTCTATTACGGCGCCTATAAGAGCGCGAAAA
TCTCCTACAACCTCGAGACCCTGCGCCTGTTCATGGCGGATTTCCCCGCCGTCGGTTTCGAGCGCGAGGATGCGCTGGAA
TCGGGAGAGATCCGCGCGGCATTGGCAGCAAAGGGAACGCCGATCGGTCCCTATGATGTGCTGATCGCCGCCCAGGCGAA
GACCCGTGACCTCGTTCTCATCACGAACAATGTCGGGGAGTTCCGGCGCGTGGATGGCCTTGATGTCGAGGATTGGACGA
TCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9907.05 Da        Isoelectric Point: 4.5271

>AT76020 WP_077988927.1 NZ_CP021127:c9189-8929 [Rhizobium sp. Kim5]
MPQYARVFQSGNSQAVRLPKEFRFDVDQVEVTREGDAVILRPRADPGMRWASLKSALERGLSDDFLAQGREQPEDEERPD
LQDLFK

Download         Length: 261 bp

>AT76020 NZ_CP021127:c9189-8929 [Rhizobium sp. Kim5]
ATGCCGCAATATGCACGCGTCTTTCAATCCGGCAATTCGCAGGCCGTCCGGCTGCCGAAGGAATTCCGCTTCGACGTCGA
CCAGGTGGAGGTGACGCGTGAAGGCGATGCGGTCATTTTGCGGCCGCGCGCCGATCCCGGCATGCGCTGGGCGTCGCTGA
AGAGCGCTCTCGAACGCGGTCTGAGCGACGATTTTCTAGCGCAAGGACGGGAGCAGCCGGAGGATGAGGAGAGGCCGGAT
CTTCAGGATCTGTTCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References