Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5123052..5123672 Replicon chromosome
Accession NZ_CP021111
Organism Bordetella genomosp. 13 strain AU7206

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag CAL15_RS23140 Protein ID WP_086080652.1
Coordinates 5123052..5123234 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CAL15_RS23145 Protein ID WP_086080653.1
Coordinates 5123277..5123672 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CAL15_RS23120 5118603..5120393 - 1791 WP_086080649.1 aspartate--tRNA ligase -
CAL15_RS23125 5120438..5121091 - 654 WP_086081258.1 DUF502 domain-containing protein -
CAL15_RS23130 5121109..5121417 - 309 WP_086080650.1 FmdB family transcriptional regulator -
CAL15_RS23135 5121618..5122904 - 1287 WP_086080651.1 putative Na+/H+ antiporter -
CAL15_RS23140 5123052..5123234 + 183 WP_086080652.1 type II toxin-antitoxin system HicA family toxin Toxin
CAL15_RS23145 5123277..5123672 + 396 WP_086080653.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CAL15_RS23150 5123692..5125317 - 1626 WP_086080654.1 GMC family oxidoreductase N-terminal domain-containing protein -
CAL15_RS23155 5125645..5126994 + 1350 WP_086080655.1 amino acid permease -
CAL15_RS23160 5127142..5128053 - 912 WP_086080656.1 4-hydroxy-tetrahydrodipicolinate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6667.79 Da        Isoelectric Point: 11.1683

>T76006 WP_086080652.1 NZ_CP021111:5123052-5123234 [Bordetella genomosp. 13]
MSSRELIKTLEHNGRILRGVKGSHHVYSHPSKPGHISVPHPKKDLGVGLVNRLLKQADLK

Download         Length: 183 bp

>T76006 NZ_CP021111:5123052-5123234 [Bordetella genomosp. 13]
ATGAGCAGTCGAGAACTCATCAAGACGCTCGAGCACAACGGCCGGATATTGCGCGGGGTCAAAGGATCACATCACGTGTA
TTCGCACCCGAGCAAACCCGGTCATATCAGCGTGCCCCATCCTAAAAAGGACCTGGGCGTCGGATTGGTCAATCGATTGC
TGAAACAAGCAGACCTGAAGTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14238.20 Da        Isoelectric Point: 4.4482

>AT76006 WP_086080653.1 NZ_CP021111:5123277-5123672 [Bordetella genomosp. 13]
MKYPIAIEPGNHTQAWGVVVPDLPGCFSAADDGIDQAIEQAKEAISLWIETALDDGAVIPPPSRITDLQAAHPEFAGWVW
AIVEIDPAVMDDTIERVNITLPRRILARIDARARAAGETRSGYIAHMALSR

Download         Length: 396 bp

>AT76006 NZ_CP021111:5123277-5123672 [Bordetella genomosp. 13]
ATGAAATATCCCATCGCCATCGAACCCGGTAACCACACACAGGCTTGGGGCGTCGTCGTACCCGACCTTCCGGGATGTTT
CTCGGCCGCCGATGACGGCATCGATCAAGCTATCGAGCAAGCCAAGGAAGCTATCAGCCTATGGATCGAGACGGCACTGG
ATGACGGAGCTGTCATTCCTCCACCCAGCCGTATCACGGACCTGCAAGCTGCCCATCCCGAGTTCGCTGGCTGGGTCTGG
GCCATCGTCGAAATAGACCCTGCCGTGATGGACGACACCATAGAGCGGGTCAACATCACATTGCCTCGCCGTATTCTTGC
GCGCATCGACGCACGCGCACGCGCAGCGGGTGAAACACGCTCAGGCTACATCGCGCATATGGCTCTGAGCCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References