Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4866443..4867029 Replicon chromosome
Accession NZ_CP021111
Organism Bordetella genomosp. 13 strain AU7206

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag CAL15_RS21935 Protein ID WP_086080430.1
Coordinates 4866736..4867029 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag CAL15_RS21930 Protein ID WP_086080429.1
Coordinates 4866443..4866730 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CAL15_RS21915 4861485..4862678 + 1194 WP_086080426.1 MFS transporter -
CAL15_RS21920 4862695..4863441 - 747 WP_086080427.1 7-cyano-7-deazaguanine synthase QueC -
CAL15_RS21925 4863565..4866414 + 2850 WP_086080428.1 phosphoenolpyruvate carboxylase -
CAL15_RS21930 4866443..4866730 - 288 WP_086080429.1 putative addiction module antidote protein Antitoxin
CAL15_RS21935 4866736..4867029 - 294 WP_086080430.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CAL15_RS21940 4867296..4868228 + 933 WP_086080431.1 3-hydroxybutyryl-CoA dehydrogenase -
CAL15_RS21945 4868274..4869026 + 753 WP_086080432.1 SDR family oxidoreductase -
CAL15_RS21950 4869099..4869881 - 783 WP_086080433.1 IclR family transcriptional regulator -
CAL15_RS21955 4870028..4870717 + 690 WP_086080434.1 3-oxoacid CoA-transferase subunit A -
CAL15_RS21960 4870714..4871358 + 645 WP_086080435.1 CoA transferase subunit B -
CAL15_RS21965 4871479..4871814 + 336 WP_086080436.1 FxLYD domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-91)

Antitoxin

Uncharacterized protein HI1420

(2-91)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11180.01 Da        Isoelectric Point: 10.8124

>T76005 WP_086080430.1 NZ_CP021111:c4867029-4866736 [Bordetella genomosp. 13]
MTELLQTDTFKDWMHRLRDTRARTAIAARLARLAAGLAGDVEPVGGGVFEMRVHHGPGYRVYFKRHRDVMIILLCAGDKR
TQRRDIERAKRMVGEME

Download         Length: 294 bp

>T76005 NZ_CP021111:c4867029-4866736 [Bordetella genomosp. 13]
ATGACCGAACTCCTGCAGACCGACACTTTCAAAGATTGGATGCATCGCTTGCGCGACACTCGCGCGCGCACCGCTATCGC
CGCACGCCTTGCAAGGTTGGCCGCCGGACTGGCTGGTGACGTGGAACCGGTCGGCGGCGGCGTATTCGAAATGCGCGTCC
ACCATGGCCCAGGATACCGGGTCTACTTCAAGCGCCACCGCGATGTCATGATCATCCTCCTTTGCGCGGGCGACAAGCGT
ACGCAACGCAGAGACATCGAGCGGGCCAAGCGCATGGTCGGAGAAATGGAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 9981.60 Da        Isoelectric Point: 8.4594

>AT76005 WP_086080429.1 NZ_CP021111:c4866730-4866443 [Bordetella genomosp. 13]
MKTKLTPYDPATALVDDAEIAFFMADALKTGDAAYIAQALGIVARAKGMAEVARNTGLSREQLYRSLSADGNPTLKTTLA
VLKALGIELTAKLPA

Download         Length: 288 bp

>AT76005 NZ_CP021111:c4866730-4866443 [Bordetella genomosp. 13]
ATGAAAACCAAGCTGACGCCATACGATCCCGCCACGGCACTTGTCGATGATGCCGAAATCGCCTTCTTCATGGCGGACGC
GTTGAAGACCGGCGACGCTGCATACATCGCCCAGGCGCTAGGCATAGTCGCCCGCGCAAAAGGCATGGCGGAAGTCGCGC
GCAATACCGGTTTGTCGCGGGAGCAGCTCTACCGTTCATTGAGTGCCGACGGGAATCCCACGCTCAAGACCACGCTGGCA
GTATTGAAAGCACTGGGCATCGAATTGACGGCCAAGCTTCCGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References