Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) FicTA/Fic(toxin)
Location 4222151..4222941 Replicon chromosome
Accession NZ_CP021111
Organism Bordetella genomosp. 13 strain AU7206

Toxin (Protein)


Gene name VbhT Uniprot ID -
Locus tag CAL15_RS19070 Protein ID WP_086079934.1
Coordinates 4222151..4222756 (-) Length 202 a.a.

Antitoxin (Protein)


Gene name VbhA Uniprot ID -
Locus tag CAL15_RS19075 Protein ID WP_086081183.1
Coordinates 4222753..4222941 (-) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CAL15_RS19045 4217885..4218124 + 240 WP_086079929.1 Fis family transcriptional regulator -
CAL15_RS19050 4218141..4219730 + 1590 WP_086079930.1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase -
CAL15_RS19055 4219735..4220283 + 549 WP_086079931.1 crossover junction endodeoxyribonuclease RuvC -
CAL15_RS19060 4220444..4221016 + 573 WP_086079932.1 Holliday junction branch migration protein RuvA -
CAL15_RS19065 4221080..4222021 - 942 WP_086079933.1 complex I NDUFA9 subunit family protein -
CAL15_RS19070 4222151..4222756 - 606 WP_086079934.1 Fic/DOC family protein Toxin
CAL15_RS19075 4222753..4222941 - 189 WP_086081183.1 antitoxin VbhA family protein Antitoxin
CAL15_RS19080 4223091..4224059 - 969 WP_086081184.1 threo-3-hydroxy-L-aspartate ammonia-lyase -
CAL15_RS19085 4224245..4225321 + 1077 WP_086079935.1 Holliday junction branch migration DNA helicase RuvB -
CAL15_RS19090 4225959..4227773 - 1815 WP_086079936.1 DNA helicase RecQ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(55-152)

Antitoxin

Antitoxin VbhA-like

(9-51)


Sequences

Toxin        


Download         Length: 202 a.a.        Molecular weight: 22399.22 Da        Isoelectric Point: 7.1867

>T76003 WP_086079934.1 NZ_CP021111:c4222756-4222151 [Bordetella genomosp. 13]
MKYAGDRGDPYLYSGTEVLRNLLGIKNQGALDKVESTLSFLRAAELREHPVAGHFDLPHLLQIHARLFGDVYDWAGQVRS
VEIRKGHTVFARKLMIESAAGRLFDQLAGENHLRGLDPDQFSQRAGHYLGEINVLHPFREGNGRTQREFMGQLARQAGLR
IDWSAASQDEMVRASIDAYNGDSSGLSRLIRACLADPADRA

Download         Length: 606 bp

>T76003 NZ_CP021111:c4222756-4222151 [Bordetella genomosp. 13]
ATGAAATACGCAGGAGACCGCGGCGATCCGTACCTGTACAGCGGCACGGAGGTGTTGCGCAACCTGCTGGGCATCAAGAA
TCAGGGTGCGCTCGACAAGGTCGAGTCCACCCTTTCTTTTTTGCGCGCGGCCGAACTTCGCGAGCATCCGGTCGCGGGTC
ATTTCGACCTGCCGCACCTGCTGCAGATCCATGCCCGCCTGTTCGGCGACGTCTACGACTGGGCCGGCCAGGTGCGAAGC
GTGGAAATACGGAAAGGCCACACCGTGTTCGCCCGCAAGCTCATGATCGAAAGCGCGGCGGGCCGGCTGTTCGACCAACT
GGCCGGCGAGAACCATCTGCGCGGATTGGATCCCGACCAGTTCAGCCAGCGTGCCGGACACTATCTCGGCGAGATCAACG
TGCTGCATCCGTTCCGCGAAGGCAACGGCCGCACGCAGCGCGAATTCATGGGCCAGCTGGCGCGCCAGGCCGGGCTGCGC
ATCGACTGGAGTGCGGCTAGCCAGGACGAGATGGTGCGTGCCTCCATCGACGCGTACAACGGCGATTCCAGCGGACTATC
CCGCCTGATCCGCGCCTGCCTGGCCGACCCCGCGGACCGCGCCTAG

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6934.95 Da        Isoelectric Point: 5.6664

>AT76003 WP_086081183.1 NZ_CP021111:c4222941-4222753 [Bordetella genomosp. 13]
MLAEHEHFERLAAVRSALASQRMEGLEPDPRAVADAERWARGEITIGAAVADFKMRVRLEMA

Download         Length: 189 bp

>AT76003 NZ_CP021111:c4222941-4222753 [Bordetella genomosp. 13]
CTGCTGGCCGAACACGAACACTTCGAGCGATTGGCAGCCGTGCGCAGCGCGCTGGCCAGCCAGCGCATGGAAGGGCTCGA
GCCCGATCCCCGGGCGGTGGCCGATGCCGAGCGCTGGGCGCGCGGCGAAATCACCATCGGCGCCGCCGTGGCCGATTTCA
AGATGCGAGTGCGCCTAGAAATGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References