Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 1243581..1244195 Replicon chromosome
Accession NZ_CP021111
Organism Bordetella genomosp. 13 strain AU7206

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag CAL15_RS05685 Protein ID WP_086077694.1
Coordinates 1243581..1243877 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag CAL15_RS05690 Protein ID WP_086077695.1
Coordinates 1243896..1244195 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CAL15_RS05670 1239409..1239852 + 444 WP_086077691.1 type III secretion system chaperone -
CAL15_RS05675 1239849..1242113 + 2265 WP_086077692.1 hypothetical protein -
CAL15_RS05680 1242296..1243444 + 1149 WP_086077693.1 mechanosensitive ion channel -
CAL15_RS05685 1243581..1243877 + 297 WP_086077694.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CAL15_RS05690 1243896..1244195 + 300 WP_086077695.1 putative addiction module antidote protein Antitoxin
CAL15_RS05695 1244213..1245196 - 984 WP_086077696.1 tripartite tricarboxylate transporter substrate binding protein -
CAL15_RS05700 1245317..1246408 - 1092 WP_086077697.1 tartrate dehydrogenase -
CAL15_RS05705 1246574..1248544 - 1971 WP_198299235.1 gamma-glutamyltransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-92)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10978.58 Da        Isoelectric Point: 10.2764

>T76000 WP_086077694.1 NZ_CP021111:1243581-1243877 [Bordetella genomosp. 13]
MANRTIHTTSVFDKWFAGLKDKRAVRRIQVRIDRAEDGNFGDCESIGAGVFEMRIHYGPGYRVYFVSRGVDIVILLAGGD
KATQSKDIRTALNLARAF

Download         Length: 297 bp

>T76000 NZ_CP021111:1243581-1243877 [Bordetella genomosp. 13]
ATGGCTAACAGGACCATTCATACAACGTCAGTCTTTGACAAGTGGTTTGCCGGTCTGAAGGACAAGCGAGCGGTGCGCCG
AATCCAGGTGCGTATCGATCGTGCCGAAGACGGAAATTTTGGCGACTGCGAGTCCATCGGGGCGGGTGTATTCGAGATGC
GGATCCACTATGGTCCCGGCTACCGTGTGTATTTCGTCTCACGCGGCGTGGATATTGTGATTTTGCTGGCAGGGGGCGAC
AAGGCCACTCAGTCGAAGGACATAAGAACCGCCTTGAACCTCGCAAGAGCATTCTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10662.18 Da        Isoelectric Point: 4.8227

>AT76000 WP_086077695.1 NZ_CP021111:1243896-1244195 [Bordetella genomosp. 13]
MNATTLREWDSAEYLKTDEDMVLYLEACMEEAGDDAAFIAKALGNIARAKGMTQLAKETGLGRESLYKALSGEGNPSFAT
ILKVTRALGIKLHPQAATP

Download         Length: 300 bp

>AT76000 NZ_CP021111:1243896-1244195 [Bordetella genomosp. 13]
ATGAACGCCACGACACTACGCGAGTGGGATAGCGCCGAGTATCTCAAGACCGATGAGGATATGGTGCTGTATCTTGAGGC
CTGCATGGAAGAGGCCGGCGACGACGCAGCCTTTATTGCCAAGGCGCTTGGCAACATCGCCCGGGCGAAGGGGATGACGC
AGCTGGCCAAAGAAACCGGTCTGGGCCGGGAGAGCCTCTACAAGGCACTCTCAGGCGAAGGAAACCCTAGCTTTGCCACG
ATCCTCAAGGTCACCCGGGCGCTTGGCATAAAGCTGCACCCGCAAGCGGCGACGCCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References