Detailed information of TA system TA075996

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1884662..1885332
• Replicon: chromosome
• Accession: NZ_CP021110
• Organism: Bordetella genomosp. 9 strain AU14267

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CAL14_RS08845
• Protein ID: WP_086057152.1
• Coordinates: 1884913..1885332 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: CAL14_RS08840
• Protein ID: WP_086057151.1
• Coordinates: 1884662..1884916 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CAL14_RS08830	1881147..1882607	+	1461	WP_086057149.1	IMP dehydrogenase	-
CAL14_RS08835	1882714..1884306	+	1593	WP_086057150.1	glutamine-hydrolyzing GMP synthase	-
CAL14_RS08840	1884662..1884916	+	255	WP_086057151.1	Arc family DNA-binding protein	Antitoxin
CAL14_RS08845	1884913..1885332	+	420	WP_086057152.1	type II toxin-antitoxin system VapC family toxin	Toxin
CAL14_RS20920	1885580..1885939	+	360	WP_198297752.1	hypothetical protein	-
CAL14_RS20745	1886298..1888118	+	1821	WP_157664438.1	hypothetical protein	-
CAL14_RS20750	1888165..1888517	+	353	Protein_1729	IS3 family transposase	-
CAL14_RS08865	1888854..1889312	+	459	WP_086057153.1	hypothetical protein	-
CAL14_RS08870	1889270..1889551	+	282	WP_157664439.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-123)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14865.11 Da
• Isoelectric Point: 5.1786

>T75996 WP_086057152.1 NZ_CP021110:1884913-1885332 [Bordetella genomosp. 9]
MIVLDTNVVSEAMKPEPNPAVRAWLNEQVAETLYLSSVTLAELLFGIGALPNGRRRKGLGEALDGLLGLFGERVLMFDTE
AARHYAELAVKARTAGKGFPTPDGYIAAIAAAKGFIVATRDTSPFEAAGLTVINPWDHL

Nucleotide

• Length: 420 bp

>T75996 NZ_CP021110:1884913-1885332 [Bordetella genomosp. 9]
ATGATCGTCTTGGATACGAATGTCGTCTCCGAGGCGATGAAACCCGAACCCAACCCGGCTGTGCGAGCTTGGTTGAATGA
GCAGGTAGCGGAAACCCTTTACCTGTCCAGCGTGACGCTGGCCGAGCTGCTGTTTGGCATCGGCGCGTTGCCGAACGGGA
GGCGTAGGAAAGGCCTGGGCGAAGCCCTGGACGGCTTGCTCGGACTCTTCGGCGAGCGGGTGTTGATGTTCGACACCGAA
GCGGCTCGCCATTATGCCGAGCTGGCGGTAAAGGCCCGCACAGCTGGGAAGGGTTTCCCAACACCCGACGGATATATTGC
GGCTATTGCGGCCGCCAAAGGATTTATCGTAGCAACACGCGATACCAGCCCTTTTGAAGCGGCTGGGCTTACTGTTATCA
ATCCTTGGGACCATCTGTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9440.70 Da
• Isoelectric Point: 5.1786

>AT75996 WP_086057151.1 NZ_CP021110:1884662-1884916 [Bordetella genomosp. 9]
MAILTVRNVPDEVHRALRLRAAEHGRSTEAEVREILERAVKSETRVRMGDALAELGSRVGLTNDDFAVLDQVRDTVPAEP
MRFE

Nucleotide

• Length: 255 bp

>AT75996 NZ_CP021110:1884662-1884916 [Bordetella genomosp. 9]
ATGGCCATCCTGACAGTGCGAAATGTGCCTGATGAGGTGCATCGCGCTCTGCGCTTACGGGCCGCCGAGCATGGCCGCAG
CACAGAGGCGGAGGTGCGCGAGATTCTGGAAAGGGCGGTGAAGTCGGAGACGCGTGTCCGCATGGGCGACGCTCTGGCAG
AGCTTGGCAGCCGTGTTGGGCTGACAAACGACGATTTCGCTGTGTTGGACCAAGTGCGAGACACAGTGCCGGCAGAACCG
ATGAGGTTTGAATGA