Detailed information of TA system TA075994

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 665900..666539
• Replicon: chromosome
• Accession: NZ_CP021109
• Organism: Bordetella genomosp. 9 strain AU17164

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CAL13_RS03075
• Protein ID: WP_086071476.1
• Coordinates: 665900..666316 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: CAL13_RS03080
• Protein ID: WP_086073489.1
• Coordinates: 666303..666539 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CAL13_RS03070	662455..664848	-	2394	WP_086071475.1	ATP-dependent endonuclease	-
CAL13_RS03075	665900..666316	-	417	WP_086071476.1	type II toxin-antitoxin system VapC family toxin	Toxin
CAL13_RS03080	666303..666539	-	237	WP_086073489.1	DNA-binding protein	Antitoxin
CAL13_RS03085	666770..667649	-	880	Protein_609	LysR family transcriptional regulator	-
CAL13_RS03090	667755..667949	-	195	WP_086071477.1	hypothetical protein	-
CAL13_RS03095	668013..670079	-	2067	WP_086071478.1	pyridoxamine 5'-phosphate oxidase family protein	-
CAL13_RS03100	670140..670751	-	612	WP_086071479.1	glutathione S-transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15289.53 Da
• Isoelectric Point: 8.5678

>T75994 WP_086071476.1 NZ_CP021109:c666316-665900 [Bordetella genomosp. 9]
VYLVDTNVISEVRKGSRANAGVIQFFRNAVAEDREVYLSAVTVGELRRSVTLIRHRGDIAQAKSLEAWLQIVLREYGSNI
LPIGAEIAEVWGRLRVPRPEHALDKLIAATALIHDLTVVSRNIDDFVGTGSRVLNPFS

Nucleotide

• Length: 417 bp

>T75994 NZ_CP021109:c666316-665900 [Bordetella genomosp. 9]
GTGTACTTGGTTGATACGAACGTCATTAGCGAGGTGAGGAAGGGAAGTCGCGCCAATGCCGGTGTAATTCAATTCTTCCG
CAATGCGGTGGCCGAGGACCGAGAGGTATACCTTTCCGCCGTAACAGTGGGAGAGCTGCGCAGAAGCGTCACACTGATTC
GCCATCGTGGCGATATCGCGCAGGCGAAGTCATTGGAAGCTTGGCTTCAAATCGTTCTGCGTGAATACGGGTCCAACATC
TTGCCAATCGGCGCCGAGATCGCCGAGGTATGGGGGCGTCTCCGAGTGCCGCGTCCGGAACACGCCCTGGACAAGCTCAT
CGCGGCGACGGCGCTGATCCACGACCTTACCGTGGTGTCCCGGAACATTGATGATTTCGTAGGTACTGGAAGCCGAGTAT
TGAATCCCTTCTCGTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8371.59 Da
• Isoelectric Point: 6.4654

>AT75994 WP_086073489.1 NZ_CP021109:c666539-666303 [Bordetella genomosp. 9]
MASLLVRGVDEALVQTLREVAAAHGRSAEAEHREILARALRRPIRKSLAEVLMSIPDVGKDADFQRVNDAAEGPGVLG

Nucleotide

• Length: 237 bp

>AT75994 NZ_CP021109:c666539-666303 [Bordetella genomosp. 9]
ATGGCCAGTCTATTGGTCCGGGGAGTGGATGAAGCTCTTGTCCAAACCTTACGCGAGGTGGCGGCCGCACACGGCCGGAG
CGCGGAAGCGGAACACCGCGAGATCCTTGCCCGCGCGCTCCGACGGCCGATCCGAAAAAGCCTTGCCGAAGTACTGATGA
GCATTCCGGATGTTGGTAAGGACGCCGACTTCCAGCGCGTAAACGACGCTGCAGAGGGCCCCGGTGTACTTGGTTGA