75992

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 381429..382468 Replicon chromosome
Accession NZ_CP021109
Organism Bordetella genomosp. 9 strain AU17164

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag CAL13_RS01780 Protein ID WP_086071312.1
Coordinates 381429..382004 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag CAL13_RS01785 Protein ID WP_086071313.1
Coordinates 382001..382468 (-) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CAL13_RS21105 376589..376705 - 117 Protein_346 TIGR03749 family integrating conjugative element protein -
CAL13_RS01755 376746..377690 + 945 WP_086071308.1 ATP-binding protein -
CAL13_RS01760 377852..378070 + 219 Protein_348 hypothetical protein -
CAL13_RS01765 378307..378825 + 519 WP_086071309.1 hypothetical protein -
CAL13_RS01770 378970..379380 + 411 WP_086071310.1 hypothetical protein -
CAL13_RS01775 379546..381075 + 1530 WP_086071311.1 sensor domain-containing diguanylate cyclase -
CAL13_RS01780 381429..382004 - 576 WP_086071312.1 PIN domain-containing protein Toxin
CAL13_RS01785 382001..382468 - 468 WP_086071313.1 helix-turn-helix domain-containing protein Antitoxin
CAL13_RS01795 383293..385833 - 2541 WP_086071314.1 autotransporter outer membrane beta-barrel domain-containing protein -
CAL13_RS01805 387033..387449 - 417 WP_086071315.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 331398..466043 134645
- flank IS/Tn - - 386748..387008 260


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(84-132)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21578.58 Da        Isoelectric Point: 5.2737

>T75992 WP_086071312.1 NZ_CP021109:c382004-381429 [Bordetella genomosp. 9]
MRHSSFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSRAIHDEWKRNLLTNRPDLTQAQVDRTSDLMDRAIPDALVEGY
EALVAGLALPDPDDRHVLAAAIRCGASVIVTFNQRDFPTEMLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLRE
PAIDVDRYLDILLRQGLVQTTRTLATYRTIL

Download         Length: 576 bp

>T75992 NZ_CP021109:c382004-381429 [Bordetella genomosp. 9]
ATGAGGCATTCCTCCTTCACCGCCGTCTACGACGCATGTGTCCTCTATCCGGCGCCTCTGCGGGATTTCTTAATGTGGTT
GGGACTGTCTGGGCGGTTTCGGGCGCGGTGGAGCCGGGCTATTCACGATGAGTGGAAACGGAACCTGCTGACCAACCGGC
CAGATCTCACCCAGGCCCAGGTCGACCGCACATCCGACCTGATGGATCGCGCTATCCCGGACGCCTTGGTGGAGGGATAC
GAAGCGCTCGTGGCTGGGCTGGCGTTGCCAGATCCAGACGACCGCCATGTGCTGGCTGCGGCGATTCGCTGTGGCGCGAG
CGTGATCGTGACATTCAACCAGCGGGATTTCCCGACAGAGATGCTGGCGCCCTACGGCATCGAATCGCAGCATCCCGACG
AGTTCGTGGACAACCTGTTGGACCTGGACGCGGCAGCGGTCGTGTCGGCGGCGCAACGCCAGCGTGCTCAACTCAGGGAG
CCCGCGATTGATGTGGACCGTTACCTCGACATTTTGCTGCGCCAAGGCCTGGTTCAAACGACCAGGACCCTCGCGACTTA
CCGCACCATTCTTTGA

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17291.61 Da        Isoelectric Point: 5.5722

>AT75992 WP_086071313.1 NZ_CP021109:c382468-382001 [Bordetella genomosp. 9]
MTNTAQSKMTLPAEGEVKAAVQGQRALAAYLATQFETQHIQIFDDQKQAHEVELPTSALRLLVDILAELADGNAVKVVPV
HAELTTQEAADLLNVSRPHFVRLLEDGVLPFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 468 bp

>AT75992 NZ_CP021109:c382468-382001 [Bordetella genomosp. 9]
ATGACCAACACTGCCCAATCCAAGATGACCTTGCCCGCTGAGGGGGAGGTGAAAGCGGCCGTGCAGGGTCAGCGTGCCCT
GGCAGCCTATTTGGCGACTCAATTCGAAACGCAACACATTCAGATTTTCGATGACCAGAAACAAGCGCACGAAGTAGAAC
TGCCCACCTCGGCGCTGCGCCTGCTCGTTGACATCCTGGCCGAACTTGCCGACGGGAACGCCGTGAAGGTGGTACCAGTC
CATGCAGAGTTAACGACCCAAGAGGCGGCGGACCTGCTTAACGTCTCTCGCCCGCATTTCGTCAGGTTGCTCGAAGACGG
TGTGTTGCCGTTTCATCGGACTGGCAAGCACCGCAGGGTAAGGTTTGCCGACCTGATGCAGTACAAAGAAGCACGTGAAC
GCGCTAGTGAACAAGCAATGGCGGAACTCGCCCAGCAGTCGCAGGAGCTGGGAATGGGGTACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References