Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1838964..1839529 Replicon chromosome
Accession NZ_CP021108
Organism Bordetella genomosp. 8 strain AU19157

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CAL12_RS08470 Protein ID WP_086064087.1
Coordinates 1838964..1839335 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CAL12_RS08475 Protein ID WP_086064088.1
Coordinates 1839332..1839529 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CAL12_RS08450 1834128..1834580 - 453 WP_086064084.1 DNA polymerase III subunit chi -
CAL12_RS08455 1834603..1836114 - 1512 WP_086067752.1 leucyl aminopeptidase -
CAL12_RS08460 1836177..1837316 + 1140 WP_086064085.1 LPS export ABC transporter permease LptF -
CAL12_RS08465 1837444..1838937 + 1494 WP_086064086.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
CAL12_RS08470 1838964..1839335 - 372 WP_086064087.1 type II toxin-antitoxin system VapC family toxin Toxin
CAL12_RS08475 1839332..1839529 - 198 WP_086064088.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CAL12_RS08480 1839709..1840650 + 942 WP_086064089.1 CysB family HTH-type transcriptional regulator -
CAL12_RS08485 1840831..1841157 + 327 WP_086064090.1 DUF2325 domain-containing protein -
CAL12_RS08490 1841118..1842362 + 1245 WP_157792923.1 glycosyltransferase -
CAL12_RS08495 1842419..1843105 - 687 WP_086064092.1 C40 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-112)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-44)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13372.51 Da        Isoelectric Point: 5.0604

>T75989 WP_086064087.1 NZ_CP021108:c1839335-1838964 [Bordetella genomosp. 8]
MILVDTSVWIDHINAADPVLVDLLTNGLVLAHPFVIAEIALGSLKNRETVLGALRDLPNAPVATPDETLFLIEREQLFNR
GIGYVDTSLLASARLQPGTTLWTRDKRLAKAADALGLTPQLLH

Download         Length: 372 bp

>T75989 NZ_CP021108:c1839335-1838964 [Bordetella genomosp. 8]
ATGATCTTGGTCGATACGTCCGTATGGATCGACCACATCAATGCGGCCGACCCCGTTCTGGTTGACTTGCTGACGAACGG
ACTAGTCCTCGCGCATCCCTTCGTGATCGCCGAGATTGCATTGGGCAGCCTGAAAAATCGTGAGACCGTGCTCGGCGCGT
TGCGCGATCTACCGAACGCGCCGGTTGCCACGCCCGATGAAACGCTCTTTCTCATCGAGCGCGAACAACTATTCAATCGC
GGCATTGGTTACGTGGACACATCGCTGCTGGCCTCCGCACGATTGCAGCCCGGCACGACCCTGTGGACTCGGGACAAACG
GCTTGCAAAGGCTGCGGATGCACTGGGATTGACACCCCAGTTGCTGCACTAG

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7048.09 Da        Isoelectric Point: 9.9948

>AT75989 WP_086064088.1 NZ_CP021108:c1839529-1839332 [Bordetella genomosp. 8]
MRTTIALDDDLLSKAQAYTGLEEKTALVREALKALIQREAAKRLIALGGSQPGVEAAPRRRQGTE

Download         Length: 198 bp

>AT75989 NZ_CP021108:c1839529-1839332 [Bordetella genomosp. 8]
ATGCGAACCACAATCGCACTCGATGACGATCTTCTATCCAAGGCACAAGCCTACACCGGCCTCGAAGAGAAAACGGCGCT
GGTACGTGAAGCACTCAAGGCCCTGATCCAGCGCGAAGCGGCCAAGCGGCTTATCGCCCTGGGCGGAAGCCAACCCGGCG
TTGAAGCCGCCCCGCGCCGTCGGCAGGGCACGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References