Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 316680..317230 Replicon chromosome
Accession NZ_CP021108
Organism Bordetella genomosp. 8 strain AU19157

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag CAL12_RS01495 Protein ID WP_198298450.1
Coordinates 316901..317230 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag CAL12_RS01490 Protein ID WP_086067610.1
Coordinates 316680..316904 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CAL12_RS01470 311944..312267 - 324 WP_086062860.1 XRE family transcriptional regulator -
CAL12_RS01475 312260..312459 - 200 Protein_293 type II toxin-antitoxin system RelE/ParE family toxin -
CAL12_RS01480 312709..314940 - 2232 WP_086062861.1 NADP-dependent isocitrate dehydrogenase -
CAL12_RS01485 315300..316502 + 1203 WP_086062862.1 cytochrome P450 -
CAL12_RS01490 316680..316904 + 225 WP_086067610.1 antitoxin MazE family protein Antitoxin
CAL12_RS01495 316901..317230 + 330 WP_198298450.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CAL12_RS01500 317249..318856 - 1608 WP_086062864.1 gamma-glutamyltransferase family protein -
CAL12_RS01505 318926..319879 - 954 WP_086067611.1 tripartite tricarboxylate transporter substrate binding protein -
CAL12_RS01510 320088..321089 - 1002 WP_086062865.1 isopenicillin N synthase family oxygenase -
CAL12_RS01515 321139..321870 - 732 WP_086062866.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-104)

Antitoxin

Antitoxin MazE-like

(8-72)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11811.84 Da        Isoelectric Point: 10.0069

>T75988 WP_198298450.1 NZ_CP021108:316901-317230 [Bordetella genomosp. 8]
MMRGDLVTVAVQGDFGKPRPPALVIQADLYSEHGSVTVLPVTTTLVDAPLLRITAQPSTGNGLRQPSQIMVDKAVTVRRD
KIGRPIGRIEGETLQEVERCLAVLLRIAK

Download         Length: 330 bp

>T75988 NZ_CP021108:316901-317230 [Bordetella genomosp. 8]
CTGATGCGGGGTGATCTGGTTACGGTCGCCGTGCAGGGCGATTTTGGAAAACCGCGTCCGCCGGCCCTTGTGATTCAAGC
AGATTTATACAGTGAACACGGTAGCGTGACGGTGCTGCCAGTCACCACCACGCTCGTCGATGCGCCATTACTGCGGATAA
CAGCGCAGCCGAGCACCGGCAATGGCCTCCGGCAACCGTCTCAAATCATGGTGGATAAGGCCGTAACGGTGCGGCGCGAC
AAGATAGGGCGCCCTATCGGCCGCATCGAGGGCGAGACCTTGCAGGAGGTCGAACGCTGCCTGGCCGTTTTGCTGAGAAT
CGCGAAGTAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8103.20 Da        Isoelectric Point: 6.9763

>AT75988 WP_086067610.1 NZ_CP021108:316680-316904 [Bordetella genomosp. 8]
MAGNNVNARVNKHRAALRMAGLRPVQIWVPDARLPNFAEECRRQSALVTRADAGDVGMAQLMEQAASDLDGWDV

Download         Length: 225 bp

>AT75988 NZ_CP021108:316680-316904 [Bordetella genomosp. 8]
ATGGCCGGAAATAACGTAAACGCCCGCGTCAATAAGCATCGTGCCGCTTTGCGCATGGCCGGATTGCGCCCAGTCCAGAT
TTGGGTACCTGACGCTCGTCTACCGAATTTCGCTGAAGAATGTCGCCGCCAATCGGCTTTGGTGACTCGCGCGGATGCCG
GGGATGTCGGCATGGCGCAGTTGATGGAGCAGGCTGCGTCTGACCTGGACGGCTGGGACGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References