75970

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 824292..824769 Replicon chromosome
Accession NZ_CP021105
Organism Staphylococcus aureus strain CC5

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag B4893_RS04110 Protein ID WP_000052076.1
Coordinates 824292..824480 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag B4893_RS04115 Protein ID WP_001059690.1
Coordinates 824509..824769 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B4893_RS04080 820286..820807 + 522 WP_000824482.1 hypothetical protein -
B4893_RS04085 821148..821834 + 687 WP_000141557.1 thermonuclease family protein -
B4893_RS04090 822191..822391 + 201 WP_001059082.1 cold-shock protein -
B4893_RS04095 822883..823101 - 219 WP_000005886.1 hypothetical protein -
B4893_RS04100 823163..823447 - 285 WP_001004399.1 hypothetical protein -
B4893_RS04105 823535..824104 - 570 WP_001106654.1 hypothetical protein -
B4893_RS04110 824292..824480 - 189 WP_000052076.1 hypothetical protein Toxin
B4893_RS04115 824509..824769 - 261 WP_001059690.1 hypothetical protein Antitoxin
B4893_RS04120 825110..825313 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
B4893_RS04125 825310..825546 - 237 WP_000349581.1 hypothetical protein -
B4893_RS04130 825771..826352 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
B4893_RS04135 826425..827042 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
B4893_RS04140 827197..827691 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
B4893_RS04145 828090..828512 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
B4893_RS04150 828660..829376 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T75970 WP_000052076.1 NZ_CP021105:c824480-824292 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T75970 NZ_CP021105:c824480-824292 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT75970 WP_001059690.1 NZ_CP021105:c824769-824509 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT75970 NZ_CP021105:c824769-824509 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References