Detailed information of TA system TA075958

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/-
• Location: 38878..39254
• Replicon: plasmid p13P460A-2
• Accession: NZ_CP021087
• Organism: Escherichia coli strain 13P460A

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A075MDK3
• Locus tag: BWI88_RS25555
• Protein ID: WP_000969988.1
• Coordinates: 38878..39060 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: BWI88_RS25560
• Protein ID: WP_001324224.1
• Coordinates: 39057..39254 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BWI88_RS25540	36877..37911	-	1035	WP_001190234.1	3-deoxy-7-phosphoheptulonate synthase	-
BWI88_RS25550	38471..38779	-	309	WP_000377483.1	hypothetical protein	-
BWI88_RS25555	38878..39060	-	183	WP_000969988.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BWI88_RS25560	39057..39254	-	198	WP_001324224.1	toxin-antitoxin system protein	Antitoxin
BWI88_RS25565	39936..41210	+	1275	WP_199776869.1	HlyD family secretion protein	-
BWI88_RS25570	41185..43299	+	2115	WP_001183604.1	peptidase domain-containing ABC transporter	-
BWI88_RS25575	43469..43780	-	312	WP_001259758.1	colicin V	-
BWI88_RS26680	43758..43994	-	237	WP_001323890.1	colicin V immunity protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	blaTEM-1B / tet(B) / catA1 / aadA5 / qacE / sul1 / mph(A) / sul2 / aph(3'')-Ib / aph(6)-Id / sitABCD	iroB / iroC / iroD / iroE / iroN / iutA / iucD / iucC / iucB / iucA	1..169505	169505

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-117)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6931.07 Da
• Isoelectric Point: 4.5349

>T75958 WP_000969988.1 NZ_CP021087:c39060-38878 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLIAAIELDERIGCSASLLFSLSFISVQVHDNIITV

Nucleotide

• Length: 183 bp

>T75958 NZ_CP021087:c39060-38878 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
AGCCGCCATTGAACTGGACGAACGGATTGGTTGTTCAGCCAGCCTCCTGTTCTCCCTTTCTTTTATCAGTGTACAGGTGC
ATGACAACATAATCACGGTATGA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7658.53 Da
• Isoelectric Point: 7.2046

>AT75958 WP_001324224.1 NZ_CP021087:c39254-39057 [Escherichia coli]
MDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRDEMSRKVAGK

Nucleotide

• Length: 198 bp

>AT75958 NZ_CP021087:c39254-39057 [Escherichia coli]
ATGGACCGTAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTGGAACGGCAGCATAATACCTGGTTCCGTGA
CCAGGTTGAGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCAT
GGCGGGATGAAATGAGCAGGAAAGTCGCCGGTAAATGA

Structures

Toxin

• AlphaFold DB: A0A075MDK3