Detailed information of TA system TA075957

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 4803641..4804166
• Replicon: chromosome
• Accession: NZ_CP021080
• Organism: Streptomyces pluripotens strain MUSC 135

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A221P2S4
• Locus tag: LK06_RS21700
• Protein ID: WP_039658108.1
• Coordinates: 4803641..4803904 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A221P2F9
• Locus tag: LK06_RS21705
• Protein ID: WP_039658109.1
• Coordinates: 4803897..4804166 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LK06_RS21670	4798670..4799299	-	630	WP_078858898.1	hypothetical protein	-
LK06_RS21675	4799303..4800034	-	732	WP_039658202.1	HEAT repeat domain-containing protein	-
LK06_RS21680	4800031..4800417	-	387	WP_039658200.1	hypothetical protein	-
LK06_RS21685	4801554..4801946	-	393	WP_039658199.1	PIN domain-containing protein	-
LK06_RS21690	4801943..4802209	-	267	WP_039658197.1	hypothetical protein	-
LK06_RS21695	4802904..4803623	+	720	WP_078858834.1	tyrosine-type recombinase/integrase	-
LK06_RS21700	4803641..4803904	-	264	WP_039658108.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LK06_RS21705	4803897..4804166	-	270	WP_039658109.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LK06_RS21710	4804644..4805051	-	408	Protein_4225	DNA-binding protein	-
LK06_RS33825	4805131..4805478	-	348	WP_167747928.1	hypothetical protein	-
LK06_RS32725	4805609..4805701	-	93	Protein_4227	MerR family transcriptional regulator	-
LK06_RS21720	4805889..4806077	+	189	WP_043433455.1	hypothetical protein	-
LK06_RS21725	4806074..4806760	+	687	WP_052318911.1	cytochrome b N-terminal domain-containing protein	-
LK06_RS21730	4806757..4807719	+	963	WP_043408952.1	hypothetical protein	-
LK06_RS21735	4807784..4808758	-	975	WP_039658112.1	SMP-30/gluconolactonase/LRE family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	4785949..4823909	37960

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-58)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10026.46 Da
• Isoelectric Point: 8.5041

>T75957 WP_039658108.1 NZ_CP021080:c4803904-4803641 [Streptomyces pluripotens]
VTDYRTAFRPEAQAELRKIPRDMALRILAKLAELESDPLGFNTTALVSQPERRRLRVGDYRVVYTIDNGELVVWIVHVGH
RSTVYDT

Nucleotide

• Length: 264 bp

>T75957 NZ_CP021080:c4803904-4803641 [Streptomyces pluripotens]
GTGACTGACTACCGGACCGCCTTCCGGCCCGAGGCGCAGGCCGAACTCCGGAAGATCCCCCGCGACATGGCGCTGCGCAT
CCTGGCGAAACTGGCCGAGCTGGAGAGCGACCCCCTGGGCTTCAACACCACCGCGCTCGTGTCGCAGCCAGAACGCCGTC
GGCTCCGAGTCGGCGACTACCGCGTCGTCTACACGATCGACAACGGAGAGCTGGTGGTGTGGATCGTGCACGTCGGGCAC
CGCTCCACCGTCTACGACACCTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10202.66 Da
• Isoelectric Point: 4.7473

>AT75957 WP_039658109.1 NZ_CP021080:c4804166-4803897 [Streptomyces pluripotens]
MTQPLPIESIRNVRAHLAEVVERADRDDVPTVITRRGKEVAAVVSIEVLRKYQEWEEREINRIIDERMANPAPGIPIEDV
MKETLARGD

Nucleotide

• Length: 270 bp

>AT75957 NZ_CP021080:c4804166-4803897 [Streptomyces pluripotens]
ATGACGCAGCCACTCCCCATAGAGTCCATCCGCAATGTGCGCGCGCACTTGGCCGAGGTCGTGGAGCGCGCCGATCGGGA
CGACGTACCAACGGTGATCACGCGCCGCGGCAAGGAAGTCGCCGCCGTGGTGTCGATCGAGGTGCTGCGCAAGTACCAGG
AATGGGAAGAGCGCGAGATCAACCGGATCATCGACGAGCGCATGGCCAACCCGGCACCCGGCATCCCGATCGAGGACGTC
ATGAAGGAGACGCTGGCGCGCGGTGACTGA

Structures

Toxin

• AlphaFold DB: A0A221P2S4

Antitoxin

• AlphaFold DB: A0A221P2F9