Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2032916..2033691 Replicon chromosome
Accession NZ_CP021075
Organism Burkholderia glumae strain 957856-41-c

Toxin (Protein)


Gene name TacT2 Uniprot ID C5AIF4
Locus tag B7759_RS25735 Protein ID WP_015877380.1
Coordinates 2032916..2033413 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID C5AIF5
Locus tag B7759_RS25740 Protein ID WP_015877381.1
Coordinates 2033410..2033691 (-) Length 94 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7759_RS31335 2028888..2028983 - 96 Protein_1640 IS5/IS1182 family transposase -
B7759_RS25710 (B7759_05046) 2029055..2029600 - 546 Protein_1641 IS3 family transposase -
B7759_RS25715 2029827..2030644 + 818 WP_085962346.1 IS5-like element ISBugl2 family transposase -
B7759_RS25720 2030619..2030924 - 306 WP_209954515.1 hypothetical protein -
B7759_RS31340 2030941..2031192 - 252 WP_230674552.1 hypothetical protein -
B7759_RS25725 2031319..2031924 - 606 Protein_1645 RHS repeat-associated core domain-containing protein -
B7759_RS25730 2032338..2032835 - 498 WP_015877379.1 ProQ/FINO family protein -
B7759_RS25735 (B7759_05049) 2032916..2033413 - 498 WP_015877380.1 GNAT family N-acetyltransferase Toxin
B7759_RS25740 (B7759_05050) 2033410..2033691 - 282 WP_015877381.1 DUF1778 domain-containing protein Antitoxin
B7759_RS25745 2033688..2034065 - 378 WP_173941242.1 hypothetical protein -
B7759_RS25750 (B7759_05051) 2034148..2034510 - 363 WP_017432434.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2021380..2048447 27067
- flank IS/Tn - - 2029031..2029573 542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(44-144)

Antitoxin

(5-91)


Sequences


Toxin        


Download         Length: 166 a.a.        Molecular weight: 17544.11 Da        Isoelectric Point: 9.6894

>T75953 WP_015877380.1 NZ_CP021075:c2033413-2032916 [Burkholderia glumae]
VTGWRAPEPLSDAHGLDDFDSGVASLDTWLKRRALANQRSGASRTFVATRDGRVGAYYALASGAVTLEVAPGRFRRNMPD
PIPVVVLGRLAVDRAHQGIGVGRALVRDAGLRVLHAAAAIGIRGLIVHALSDSAKAFYERVGFEASPLDPMLLLITLADL
EHALS

Download         Length: 498 bp

>T75953 NZ_CP021075:c2033413-2032916 [Burkholderia glumae]
GTGACGGGCTGGCGCGCGCCCGAACCGCTCAGCGACGCGCACGGGCTCGACGATTTCGATTCCGGCGTCGCGAGCCTCGA
CACGTGGCTCAAACGCCGTGCACTGGCCAATCAGCGTAGCGGTGCGTCGCGGACCTTTGTGGCGACGCGAGACGGTCGAG
TGGGGGCGTACTACGCACTCGCGTCCGGCGCGGTTACGCTCGAGGTCGCACCGGGCCGCTTCCGGCGCAACATGCCCGAT
CCGATACCGGTGGTTGTGCTCGGGCGTCTCGCCGTCGATCGCGCCCATCAGGGCATTGGGGTTGGGCGTGCGCTGGTACG
CGATGCCGGCTTGCGTGTGTTGCACGCCGCAGCGGCCATCGGGATTCGCGGCCTGATCGTGCATGCACTCTCGGACTCGG
CCAAGGCGTTCTATGAGCGGGTCGGCTTTGAGGCGTCGCCGCTCGATCCGATGCTGCTCCTGATCACGCTGGCCGACCTC
GAGCACGCCTTGTCATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10256.52 Da        Isoelectric Point: 5.0477

>AT75953 WP_015877381.1 NZ_CP021075:c2033691-2033410 [Burkholderia glumae]
MTSTTPRDTLNLRIRPDDRSLIDRAAAAAHKTRTDFVLDAARAAAEQTLLDQVVLSAEPQAYAAFLARLDEPVQPNEALR
QTMQTRAPWDPAA

Download         Length: 282 bp

>AT75953 NZ_CP021075:c2033691-2033410 [Burkholderia glumae]
ATGACCTCGACCACCCCACGCGACACTCTGAACCTACGCATTCGTCCTGACGATCGCAGCTTGATTGACCGCGCCGCAGC
GGCCGCCCACAAAACGCGTACCGACTTCGTTCTGGACGCAGCGCGGGCCGCCGCCGAACAGACCTTGCTCGACCAGGTTG
TTCTGAGCGCCGAGCCGCAGGCCTACGCGGCCTTCCTGGCGCGTTTGGACGAGCCCGTCCAACCGAACGAGGCATTGCGC
CAGACCATGCAGACACGCGCGCCCTGGGACCCCGCTGCGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2J9HNC8


Antitoxin

Source ID Structure
AlphaFold DB A0A2J9HNC9

References