Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 5026741..5027276 Replicon chromosome
Accession NZ_CP021070
Organism Mesorhizobium sp. WSM1497

Toxin (Protein)


Gene name relE Uniprot ID A0A807AIF1
Locus tag A9K65_RS24695 Protein ID WP_063171900.1
Coordinates 5026741..5027016 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID E8THE0
Locus tag A9K65_RS24700 Protein ID WP_013532247.1
Coordinates 5027016..5027276 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9K65_RS24670 5022764..5023675 - 912 WP_013532241.1 ABC transporter substrate-binding protein -
A9K65_RS24675 5023879..5024451 + 573 WP_013532242.1 NAD(P)H-dependent oxidoreductase -
A9K65_RS24680 5024460..5025671 - 1212 WP_064995445.1 MFS transporter -
A9K65_RS24685 5025668..5026168 - 501 WP_013532244.1 transcription antitermination factor NusB -
A9K65_RS24690 5026165..5026659 - 495 WP_013532245.1 6,7-dimethyl-8-ribityllumazine synthase -
A9K65_RS24695 5026741..5027016 - 276 WP_063171900.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A9K65_RS24700 5027016..5027276 - 261 WP_013532247.1 ribbon-helix-helix domain-containing protein Antitoxin
A9K65_RS24705 5027340..5027957 - 618 WP_064995446.1 riboflavin synthase -
A9K65_RS24710 5027970..5029085 - 1116 WP_063167764.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
A9K65_RS24715 5029088..5029567 - 480 WP_013532250.1 transcriptional regulator NrdR -
A9K65_RS24720 5029725..5030387 - 663 WP_064995447.1 hypothetical protein -
A9K65_RS24725 5030464..5031777 - 1314 WP_013532252.1 serine hydroxymethyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-42)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10674.23 Da        Isoelectric Point: 7.2041

>T75950 WP_063171900.1 NZ_CP021070:c5027016-5026741 [Mesorhizobium sp. WSM1497]
MELKWTNKALSDLVRLHDFLVLENGPAAARAVQSLTAAPARLVEYPRIGERLEEFEPREVRRILVGSYEIRYEIQNTTIS
VLRLWHTREDR

Download         Length: 276 bp

>T75950 NZ_CP021070:c5027016-5026741 [Mesorhizobium sp. WSM1497]
ATGGAGTTGAAATGGACCAACAAGGCTTTGTCCGACTTGGTCCGGCTACATGATTTTCTCGTGCTAGAAAATGGCCCGGC
GGCCGCACGTGCCGTGCAGTCGCTTACTGCCGCGCCGGCACGGTTGGTCGAATATCCGCGCATCGGTGAGAGACTGGAAG
AGTTCGAACCACGAGAAGTGCGTCGCATTTTGGTAGGCAGCTACGAAATTCGTTACGAGATACAGAACACGACAATTTCT
GTGTTGCGCCTGTGGCATACGCGAGAGGATCGATAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9646.11 Da        Isoelectric Point: 5.6994

>AT75950 WP_013532247.1 NZ_CP021070:c5027276-5027016 [Mesorhizobium sp. WSM1497]
MDTKVITAHVPLPLAEKVDQLAARLERPRGWIVKQALSAWVDLEEERRRLTLEAMADVDAGRVIDHQAVQAWAESLGTDK
PLPVPR

Download         Length: 261 bp

>AT75950 NZ_CP021070:c5027276-5027016 [Mesorhizobium sp. WSM1497]
ATGGATACAAAAGTAATCACCGCTCACGTTCCGCTGCCGCTGGCTGAAAAGGTAGATCAACTGGCTGCCCGCCTTGAGCG
CCCACGCGGCTGGATCGTCAAACAAGCTCTTTCCGCGTGGGTGGATTTGGAGGAGGAGCGCCGACGGCTCACGCTTGAAG
CAATGGCCGATGTCGACGCAGGACGGGTCATCGATCACCAGGCCGTGCAGGCGTGGGCTGAGAGTCTTGGTACCGACAAG
CCACTGCCGGTGCCTCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A807AIF1

Antitoxin

Source ID Structure
AlphaFold DB A0A436MZK2

References