Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 3340026..3340560 Replicon chromosome
Accession NZ_CP021069
Organism Burkholderia cenocepacia strain PC184 Mulks

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag B9Z07_RS32605 Protein ID WP_034174136.1
Coordinates 3340026..3340325 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag B9Z07_RS32610 Protein ID WP_006476037.1
Coordinates 3340315..3340560 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B9Z07_RS32585 3336808..3337617 + 810 WP_006476033.1 uroporphyrinogen-III C-methyltransferase -
B9Z07_RS32590 3337614..3337991 + 378 WP_105797784.1 cobalamin biosynthesis protein -
B9Z07_RS32595 3338026..3338628 + 603 WP_006476035.1 cob(I)yrinic acid a,c-diamide adenosyltransferase -
B9Z07_RS32600 3338631..3339935 + 1305 WP_105797783.1 cobyrinate a,c-diamide synthase -
B9Z07_RS32605 3340026..3340325 - 300 WP_034174136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B9Z07_RS32610 3340315..3340560 - 246 WP_006476037.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
B9Z07_RS32615 3340675..3341838 - 1164 WP_034174137.1 amidohydrolase -
B9Z07_RS32620 3342191..3343261 + 1071 WP_034174138.1 hypothetical protein -
B9Z07_RS32625 3343230..3344135 + 906 WP_006476040.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
B9Z07_RS32635 3344265..3345281 - 1017 WP_034174139.1 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-94)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11716.38 Da        Isoelectric Point: 6.9677

>T75947 WP_034174136.1 NZ_CP021069:c3340325-3340026 [Burkholderia cenocepacia]
MAVKGRQLRLPPLAECDLEDIWRYTAEHWSPEQAEHYYRDLIGTMEALARGKKAGRICVVRDGYFRYPAGSHVVFYRETD
ETIDVIRVLHQRMDIERHL

Download         Length: 300 bp

>T75947 NZ_CP021069:c3340325-3340026 [Burkholderia cenocepacia]
ATGGCGGTTAAAGGCAGACAACTTCGGCTGCCCCCGTTGGCTGAATGCGATCTTGAAGACATTTGGCGCTATACCGCCGA
GCATTGGTCGCCTGAGCAGGCAGAGCACTATTACCGCGATCTGATTGGCACCATGGAAGCGCTGGCGCGCGGTAAAAAAG
CGGGGCGGATTTGCGTTGTTCGCGACGGATATTTTCGCTACCCCGCTGGCTCTCACGTTGTGTTCTATCGCGAAACGGAT
GAAACCATCGACGTCATCCGTGTCCTGCATCAACGGATGGACATCGAACGACATCTGTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8650.65 Da        Isoelectric Point: 8.7785

>AT75947 WP_006476037.1 NZ_CP021069:c3340560-3340315 [Burkholderia cenocepacia]
MSRNTSVSLGDHFAAFVDAQVRSGRYGSASDVVRAGLRLLESHETQMRALQEALKAGEGSGTPKPFDSEAFLARMRATHG
G

Download         Length: 246 bp

>AT75947 NZ_CP021069:c3340560-3340315 [Burkholderia cenocepacia]
ATGTCGCGAAACACATCCGTTTCCCTTGGCGATCACTTTGCAGCATTTGTCGATGCGCAGGTGCGATCGGGACGATATGG
TTCCGCAAGTGACGTCGTGCGAGCCGGGTTGCGGCTCCTCGAATCACACGAAACGCAAATGCGTGCATTGCAGGAAGCAT
TGAAGGCGGGTGAAGGGTCGGGGACGCCCAAGCCCTTCGACAGCGAGGCCTTCCTGGCCCGCATGCGGGCCACGCATGGC
GGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References