Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbE-relB/ParE-YafN
Location 2076240..2076754 Replicon chromosome
Accession NZ_CP021067
Organism Burkholderia cenocepacia strain PC184 Mulks

Toxin (Protein)


Gene name stbE Uniprot ID A0A7G6V7L5
Locus tag B9Z07_RS09470 Protein ID WP_006480332.1
Coordinates 2076240..2076458 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7G6V7L6
Locus tag B9Z07_RS09475 Protein ID WP_034175095.1
Coordinates 2076506..2076754 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B9Z07_RS09450 2071962..2072660 - 699 WP_006480336.1 MgtC/SapB family protein -
B9Z07_RS09455 2072776..2073885 + 1110 WP_023477586.1 AGE family epimerase/isomerase -
B9Z07_RS09460 2073858..2075477 - 1620 WP_023477585.1 Tar ligand binding domain-containing protein -
B9Z07_RS09465 2075756..2076199 + 444 WP_006480333.1 PaaI family thioesterase -
B9Z07_RS09470 2076240..2076458 - 219 WP_006480332.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B9Z07_RS09475 2076506..2076754 - 249 WP_034175095.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
B9Z07_RS09480 2076883..2077935 - 1053 WP_006480330.1 CoA transferase -
B9Z07_RS09485 2078061..2078825 - 765 WP_023477581.1 helix-turn-helix domain-containing protein -
B9Z07_RS09490 2078960..2079742 + 783 WP_023477580.1 crotonase/enoyl-CoA hydratase family protein -
B9Z07_RS09495 2079823..2081043 + 1221 WP_023477579.1 CoA transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-63)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8437.90 Da        Isoelectric Point: 10.6954

>T75945 WP_006480332.1 NZ_CP021067:c2076458-2076240 [Burkholderia cenocepacia]
VRDQFKAKLAERLEHPRIPSAKLHGHPDRYKIKLRGVGYRLVYEVRDAEVIVLVVAVGRRERDAVYLAEMKR

Download         Length: 219 bp

>T75945 NZ_CP021067:c2076458-2076240 [Burkholderia cenocepacia]
GTGCGCGATCAATTCAAGGCCAAGCTCGCCGAGCGGCTCGAGCATCCTCGTATCCCGTCAGCCAAATTGCATGGCCACCC
GGATCGCTACAAGATCAAGCTGCGCGGTGTCGGTTATCGCCTCGTCTACGAAGTGCGCGACGCGGAAGTCATCGTGCTGG
TGGTCGCGGTGGGCCGCCGCGAGCGTGATGCGGTCTATCTGGCTGAGATGAAACGCTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8944.25 Da        Isoelectric Point: 5.0349

>AT75945 WP_034175095.1 NZ_CP021067:c2076754-2076506 [Burkholderia cenocepacia]
MPHTILASVTASVSELKRNPMGTVAAGEGFPVAILNRNEPAFYCIPAKTWEAMVERLEDTDDNAMADSRAREKIVKVNLN
GL

Download         Length: 249 bp

>AT75945 NZ_CP021067:c2076754-2076506 [Burkholderia cenocepacia]
ATGCCTCACACCATTCTGGCTAGCGTGACGGCTAGCGTCTCGGAGCTGAAGCGGAATCCGATGGGAACCGTTGCCGCGGG
CGAGGGTTTTCCGGTCGCCATCCTGAATCGCAACGAACCCGCGTTCTACTGCATTCCAGCGAAGACGTGGGAGGCGATGG
TCGAACGCCTGGAAGACACCGACGACAATGCGATGGCCGATTCGCGCGCCAGGGAGAAGATCGTCAAGGTCAATTTGAAT
GGCCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G6V7L5

Antitoxin

Source ID Structure
AlphaFold DB A0A7G6V7L6

References