Detailed information of TA system TA075944

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 1901275..1901840
• Replicon: chromosome
• Accession: NZ_CP021067
• Organism: Burkholderia cenocepacia strain PC184 Mulks

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: B9Z07_RS08625
• Protein ID: WP_006480479.1
• Coordinates: 1901469..1901840 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A7G6V745
• Locus tag: B9Z07_RS08620
• Protein ID: WP_023477058.1
• Coordinates: 1901275..1901472 (+)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B9Z07_RS08595	1896612..1897067	-	456	WP_006480483.1	RbsD/FucU family protein	-
B9Z07_RS08600	1897146..1897538	-	393	WP_006480482.1	nuclear transport factor 2 family protein	-
B9Z07_RS08605	1897721..1899274	-	1554	WP_023477056.1	galactarate dehydratase	-
B9Z07_RS08610	1899504..1900418	+	915	WP_006480481.1	5-dehydro-4-deoxyglucarate dehydratase	-
B9Z07_RS08615	1900535..1901089	-	555	WP_006480480.1	hypothetical protein	-
B9Z07_RS08620	1901275..1901472	+	198	WP_023477058.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
B9Z07_RS08625	1901469..1901840	+	372	WP_006480479.1	PIN domain-containing protein	Toxin
B9Z07_RS08630	1901968..1903545	-	1578	WP_034175134.1	aldehyde dehydrogenase (NADP(+))	-
B9Z07_RS08635	1903832..1905184	+	1353	WP_175769605.1	MFS transporter	-
B9Z07_RS08640	1905250..1905975	-	726	WP_006480476.1	site-2 protease family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-46)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13537.58 Da
• Isoelectric Point: 5.9735

>T75944 WP_006480479.1 NZ_CP021067:1901469-1901840 [Burkholderia cenocepacia]
MILVDTSVWIDHLRAGDATLTALLEAERVLNHPFIVGELALGSMRNRETVLDALRDLPAATLATDDEVQRMIDAVPLHGL
GIGYVDAHLLASARLTSDSRLWTRDRRLLAAAERLQLVARPAH

Nucleotide

• Length: 372 bp

>T75944 NZ_CP021067:1901469-1901840 [Burkholderia cenocepacia]
ATGATCCTTGTCGACACGTCCGTCTGGATCGATCACTTGCGAGCCGGCGACGCGACGCTCACCGCATTGCTGGAAGCGGA
GCGAGTATTGAACCATCCGTTCATCGTCGGCGAGCTTGCGCTCGGCAGCATGCGCAATCGCGAGACCGTGCTAGATGCGC
TGCGCGACCTTCCAGCTGCAACCCTTGCCACCGACGACGAAGTCCAGCGCATGATCGATGCCGTACCGCTTCACGGGCTG
GGCATCGGCTACGTCGATGCCCACCTGCTTGCGTCGGCCAGACTGACCAGCGACAGCAGGCTATGGACGCGCGACCGGCG
CCTGCTGGCGGCAGCGGAGCGCCTCCAACTCGTCGCCCGCCCCGCTCACTGA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7070.14 Da
• Isoelectric Point: 10.6826

>AT75944 WP_023477058.1 NZ_CP021067:1901275-1901472 [Burkholderia cenocepacia]
MRTTLSLDDALLAKAQQLTGVTEKSALVREALRALIARESARRLARLGGTEPDLESVPRRPSELA

Nucleotide

• Length: 198 bp

>AT75944 NZ_CP021067:1901275-1901472 [Burkholderia cenocepacia]
ATGCGCACCACCTTGTCCCTCGACGACGCACTGCTCGCCAAAGCGCAGCAATTGACCGGCGTCACCGAAAAATCGGCGCT
CGTGAGGGAAGCGCTGCGCGCATTGATCGCCCGCGAAAGTGCGCGACGACTCGCCCGCCTCGGCGGCACCGAGCCTGATC
TTGAATCGGTCCCACGCCGCCCGTCGGAGCTCGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A7G6V745