Detailed information of TA system TA075943

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 1510797..1512023
• Replicon: chromosome
• Accession: NZ_CP021067
• Organism: Burkholderia cenocepacia strain PC184 Mulks

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: B9Z07_RS06915
• Protein ID: WP_006480772.1
• Coordinates: 1511442..1512023 (+)
• Length: 194 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: B9Z07_RS06910
• Protein ID: WP_006480773.1
• Coordinates: 1510797..1511363 (+)
• Length: 189 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B9Z07_RS06885	1505935..1506417	-	483	WP_006480777.1	cupin domain-containing protein	-
B9Z07_RS06890	1506728..1507381	+	654	WP_006480776.1	cysteine hydrolase	-
B9Z07_RS06895	1507407..1508138	-	732	WP_034175204.1	ribonuclease T2	-
B9Z07_RS06900	1508267..1508845	-	579	WP_034175203.1	hypothetical protein	-
B9Z07_RS06905	1508945..1510348	-	1404	WP_006480774.1	hypothetical protein	-
B9Z07_RS06910	1510797..1511363	+	567	WP_006480773.1	helix-turn-helix domain-containing protein	Antitoxin
B9Z07_RS06915	1511442..1512023	+	582	WP_006480772.1	HD domain-containing protein	Toxin
B9Z07_RS06925	1512433..1513626	+	1194	WP_034175395.1	efflux RND transporter periplasmic adaptor subunit	-
B9Z07_RS06930	1513629..1515683	+	2055	WP_006480770.1	MacB family efflux pump subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (6-165)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-64)

Sequences

Toxin

Protein

• Length: 194 a.a.
• Molecular weight: 21396.06 Da
• Isoelectric Point: 5.3083

>T75943 WP_006480772.1 NZ_CP021067:1511442-1512023 [Burkholderia cenocepacia]
MNPDTIHARLAFLREAERLKDVLRSGHTSAGRPESTAEHSWRLCLMALVFADALPGVDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERDDLLTLTASLDRAVRDEIVALWDEYEAAASPEARAAKALDKLETILQHNQGSNPPDFDYAFNLSY
GRRYTDAAPLFRAIREIVDADTQRKIDTGGYRA

Nucleotide

• Length: 582 bp

>T75943 NZ_CP021067:1511442-1512023 [Burkholderia cenocepacia]
ATGAACCCCGATACGATCCACGCGCGGCTCGCGTTCCTGCGCGAAGCCGAACGCCTGAAGGACGTGCTGCGCAGCGGCCA
CACGTCGGCCGGCCGCCCGGAAAGCACGGCCGAGCACAGCTGGCGGCTATGCCTGATGGCGCTCGTGTTCGCCGACGCGC
TGCCCGGCGTCGATACGCTGAAGCTGCTGAAACTGTGCGTCGTCCACGACCTCGGCGAGGCGCTGCACGGCGACATCCCT
GCGATCGAGCAGGCCGCGCATCCCGACAAGAGCGCACATGAACGCGACGACCTGCTGACGCTGACCGCGTCGCTCGACCG
TGCGGTGCGCGACGAGATCGTCGCGCTGTGGGACGAATACGAGGCGGCCGCCTCACCCGAAGCCCGCGCGGCGAAAGCGC
TCGACAAGCTCGAAACGATCCTGCAGCACAACCAGGGCAGCAATCCGCCCGATTTCGACTATGCGTTCAATCTCAGCTAC
GGCCGCCGCTATACCGACGCCGCGCCGCTGTTCCGCGCGATCCGCGAAATCGTCGACGCCGATACGCAGCGCAAGATCGA
CACGGGTGGGTACCGCGCATAG

Antitoxin

Protein

• Length: 189 a.a.
• Molecular weight: 20485.35 Da
• Isoelectric Point: 10.7076

>AT75943 WP_006480773.1 NZ_CP021067:1510797-1511363 [Burkholderia cenocepacia]
MPHPPLHPSSLGPQLKRWRTLHRVKQSHAAELFGVAQSTISRWEAGLQQMSPAERATAERLLAARLDSAGDHALARLIAG
SAGRMHLVCDLTHRLLASSPARAAEFSQPLSTLLGTSLWRYATPEIARMEAALDPLGWHDRAGPPSVEFDTGANASRVVP
IRGSRCRWTRLTLSDGSAVRLVETLDAH

Nucleotide

• Length: 567 bp

>AT75943 NZ_CP021067:1510797-1511363 [Burkholderia cenocepacia]
ATGCCCCACCCGCCGCTTCATCCATCCTCGCTCGGCCCGCAACTCAAGCGCTGGCGCACGCTGCACCGCGTGAAGCAAAG
CCATGCAGCCGAGCTGTTCGGCGTCGCGCAATCGACGATCTCGCGCTGGGAAGCCGGCCTTCAGCAGATGTCGCCCGCCG
AGCGCGCGACGGCCGAACGGCTGCTCGCCGCGCGCCTCGATTCCGCGGGCGACCACGCACTCGCGCGGCTGATCGCCGGC
AGCGCGGGCCGCATGCATCTCGTGTGCGACCTCACGCACCGCCTGCTGGCCAGTTCCCCGGCGCGCGCGGCCGAGTTCTC
GCAACCGCTTTCGACGTTGCTCGGCACGTCGCTGTGGCGCTACGCGACACCGGAAATCGCCCGCATGGAAGCCGCGCTCG
ACCCGCTCGGCTGGCACGACCGCGCGGGGCCGCCGAGCGTCGAGTTCGACACCGGCGCGAATGCGTCGCGCGTCGTGCCG
ATTCGCGGCAGCCGATGCCGGTGGACACGGCTGACGCTGTCGGACGGCTCGGCCGTGCGGCTCGTGGAGACGCTCGACGC
ACACTGA