Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1352001..1352656 Replicon chromosome
Accession NZ_CP021067
Organism Burkholderia cenocepacia strain PC184 Mulks

Toxin (Protein)


Gene name vapC Uniprot ID A0A7G6V5T4
Locus tag B9Z07_RS06215 Protein ID WP_006480895.1
Coordinates 1352001..1352420 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A7G6V5T5
Locus tag B9Z07_RS06220 Protein ID WP_034175232.1
Coordinates 1352417..1352656 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B9Z07_RS06190 1347440..1348234 + 795 WP_006480899.1 AraC family transcriptional regulator -
B9Z07_RS06195 1348416..1349348 + 933 WP_023477487.1 DMT family transporter -
B9Z07_RS06200 1349551..1350099 + 549 WP_023477486.1 hypothetical protein -
B9Z07_RS06205 1350193..1350327 - 135 WP_006485835.1 entericidin A/B family lipoprotein -
B9Z07_RS06210 1350562..1351857 + 1296 WP_006480896.1 aspartate carbamoyltransferase -
B9Z07_RS06215 1352001..1352420 - 420 WP_006480895.1 type II toxin-antitoxin system VapC family toxin Toxin
B9Z07_RS06220 1352417..1352656 - 240 WP_034175232.1 Arc family DNA-binding protein Antitoxin
B9Z07_RS06225 1352979..1355222 + 2244 WP_034175231.1 TonB-dependent siderophore receptor -
B9Z07_RS06230 1355226..1355981 + 756 WP_006480892.1 sel1 repeat family protein -
B9Z07_RS06235 1355978..1356661 + 684 WP_023477480.1 Fe2+-dependent dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-41)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14962.15 Da        Isoelectric Point: 4.9008

>T75941 WP_006480895.1 NZ_CP021067:c1352420-1352001 [Burkholderia cenocepacia]
MILVDTNVISEPLRREPNAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLEQSIEQRVVPLFRGRVLPFDD
AASKAYASLRAKARGTGNAMASADGFIAATAAANGLIVATRDVAPFEAAGLRVIDPWAA

Download         Length: 420 bp

>T75941 NZ_CP021067:c1352420-1352001 [Burkholderia cenocepacia]
ATGATCCTCGTCGATACCAACGTCATTTCCGAGCCGCTGCGGCGCGAGCCGAACGCGGCCGTGATCGAATGGCTCGACGC
GCAGAACGTCGAGACGCTGTTTCTTGCCGCGATCAGTCTGGCGGAAATGCGCTTCGGCGTGGCGGCGTTGCCGGAGGGCC
GTCGGCGGGACTGGCTCGAGCAAAGTATCGAGCAGCGCGTCGTGCCGTTGTTTCGCGGCCGGGTCCTGCCGTTCGATGAT
GCGGCCAGCAAGGCGTACGCGAGCCTGCGCGCCAAGGCGCGTGGTACGGGCAACGCGATGGCGTCTGCCGACGGCTTCAT
TGCCGCAACCGCCGCGGCGAACGGGCTGATCGTGGCCACGCGCGACGTCGCGCCGTTCGAGGCGGCAGGCCTGCGTGTGA
TCGACCCTTGGGCCGCCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8747.88 Da        Isoelectric Point: 6.4685

>AT75941 WP_034175232.1 NZ_CP021067:c1352656-1352417 [Burkholderia cenocepacia]
MPVITVRNLPDEVHRALRIRAAQHGRSTEAEVRDILEQAVRPGGRPRLGTLLAEIGREAGGIDFEVRRDASSTDPMSFE

Download         Length: 240 bp

>AT75941 NZ_CP021067:c1352656-1352417 [Burkholderia cenocepacia]
ATGCCCGTGATCACCGTTCGAAATTTACCCGACGAAGTGCATCGCGCGCTTCGAATCCGGGCCGCGCAACATGGCCGCAG
TACCGAAGCCGAGGTGCGAGACATTCTCGAGCAAGCCGTTCGGCCCGGCGGCCGACCCAGGCTCGGGACGCTGCTGGCTG
AAATCGGCCGGGAAGCGGGCGGCATCGATTTCGAAGTTCGGCGCGACGCATCGTCAACCGATCCGATGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G6V5T4

Antitoxin

Source ID Structure
AlphaFold DB A0A7G6V5T5

References