Detailed information of TA system TA075940

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 955923..956562
• Replicon: chromosome
• Accession: NZ_CP021067
• Organism: Burkholderia cenocepacia strain PC184 Mulks

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A3N9F707
• Locus tag: B9Z07_RS04375
• Protein ID: WP_011547639.1
• Coordinates: 955923..956333 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: B9Z07_RS04380
• Protein ID: WP_034175272.1
• Coordinates: 956326..956562 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B9Z07_RS04330	951222..951521	-	300	WP_006478972.1	hypothetical protein	-
B9Z07_RS04335	951731..951979	-	249	WP_006478971.1	hypothetical protein	-
B9Z07_RS33405	952292..952522	+	231	WP_124592124.1	hypothetical protein	-
B9Z07_RS04345	952607..952740	-	134	Protein_847	phenylacetic acid degradation protein PaaY	-
B9Z07_RS04350	952881..954251	+	1371	WP_006478970.1	MFS transporter	-
B9Z07_RS04360	954576..954839	-	264	WP_006483034.1	translation initiation factor IF-1	-
B9Z07_RS04370	955306..955509	-	204	WP_006483056.1	cold-shock protein	-
B9Z07_RS04375	955923..956333	-	411	WP_011547639.1	type II toxin-antitoxin system VapC family toxin	Toxin
B9Z07_RS04380	956326..956562	-	237	WP_034175272.1	DNA-binding protein	Antitoxin
B9Z07_RS04385	957053..958279	+	1227	WP_034174774.1	acyltransferase	-
B9Z07_RS04390	958299..958976	-	678	WP_175681298.1	hypothetical protein	-
B9Z07_RS33410	959335..959556	+	222	WP_034174773.1	hypothetical protein	-
B9Z07_RS33415	959544..959702	-	159	WP_162595466.1	hypothetical protein	-
B9Z07_RS04400	959810..961198	+	1389	WP_006478963.1	DHA2 family efflux MFS transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	948350..956562	8212

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15202.37 Da
• Isoelectric Point: 6.8816

>T75940 WP_011547639.1 NZ_CP021067:c956333-955923 [Burkholderia cenocepacia]
MIDTNVISEIRKGRRTNRGVRAFFRQAEADASPLYLSVVTVAELRRGVDLIRHRGDHSQASALEAWIAMILSGYAPNILP
VDIETSQMWGHLRVPDPTHELDKLIAATALINDLTVVTRNVDDFARTGVRLLNPFD

Nucleotide

• Length: 411 bp

>T75940 NZ_CP021067:c956333-955923 [Burkholderia cenocepacia]
TTGATTGATACCAACGTCATTAGCGAAATCAGGAAGGGCAGGCGAACCAATCGCGGCGTGCGGGCGTTCTTCAGGCAGGC
CGAAGCCGACGCCAGCCCGCTTTACCTGTCCGTCGTGACGGTGGCCGAGCTGCGGCGCGGTGTCGACCTGATCCGTCATC
GCGGCGATCATAGCCAGGCGTCGGCGCTCGAGGCCTGGATCGCGATGATCCTGTCCGGCTATGCGCCGAACATCCTGCCG
GTCGATATCGAGACCAGCCAGATGTGGGGGCATTTGCGGGTGCCCGACCCAACGCACGAACTCGACAAGCTGATCGCGGC
CACCGCGCTGATCAACGATCTGACGGTCGTCACGCGCAACGTCGACGATTTCGCTCGCACTGGCGTCCGGTTGCTGAATC
CGTTCGACTAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8634.71 Da
• Isoelectric Point: 5.8236

>AT75940 WP_034175272.1 NZ_CP021067:c956562-956326 [Burkholderia cenocepacia]
MANLLVRNVDDTIVQSLREQAAANGRSAEAEHRAILAEALGRPKRRTFAQVLLSMPEVGEGADFQRVQDSGEVRRVFD

Nucleotide

• Length: 237 bp

>AT75940 NZ_CP021067:c956562-956326 [Burkholderia cenocepacia]
ATGGCAAATCTTCTGGTGCGTAACGTGGATGACACTATCGTTCAAAGCCTGCGCGAGCAGGCGGCGGCCAATGGCAGGAG
CGCCGAGGCCGAACATCGAGCCATTCTGGCCGAAGCGCTCGGCCGGCCGAAGCGGCGGACATTTGCGCAAGTGCTGCTGA
GCATGCCGGAGGTGGGCGAGGGCGCGGATTTCCAACGTGTTCAGGATTCAGGCGAGGTCAGGCGTGTTTTTGATTGA

Structures

Toxin

• AlphaFold DB: A0A3N9F707