Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 868804..870554 Replicon chromosome
Accession NZ_CP021067
Organism Burkholderia cenocepacia strain PC184 Mulks

Toxin (Protein)


Gene name hipA Uniprot ID A0A7G6V4I5
Locus tag B9Z07_RS03960 Protein ID WP_023477873.1
Coordinates 868804..870144 (-) Length 447 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag B9Z07_RS03965 Protein ID WP_023477872.1
Coordinates 870147..870554 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B9Z07_RS03935 863863..864276 + 414 WP_023477876.1 PIN domain-containing protein -
B9Z07_RS03940 864349..865650 - 1302 WP_034174801.1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase -
B9Z07_RS03945 865855..867162 - 1308 WP_011547704.1 shikimate transporter -
B9Z07_RS03955 867520..868647 + 1128 WP_011547703.1 VOC family protein -
B9Z07_RS03960 868804..870144 - 1341 WP_023477873.1 type II toxin-antitoxin system HipA family toxin Toxin
B9Z07_RS03965 870147..870554 - 408 WP_023477872.1 helix-turn-helix domain-containing protein Antitoxin
B9Z07_RS03970 871007..871672 - 666 WP_006479024.1 cation diffusion facilitator family transporter -
B9Z07_RS03975 872075..872671 + 597 WP_034174800.1 membrane protein -
B9Z07_RS03980 872678..872995 + 318 Protein_779 alpha/beta fold hydrolase -
B9Z07_RS03990 873709..874728 + 1020 WP_006479023.1 DNA-binding protein -
B9Z07_RS03995 874898..875518 + 621 WP_006479022.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-64)


Sequences

Toxin        


Download         Length: 447 a.a.        Molecular weight: 48982.83 Da        Isoelectric Point: 7.7474

>T75939 WP_023477873.1 NZ_CP021067:c870144-868804 [Burkholderia cenocepacia]
MVARARSDRLDLWMNGIPVGYWEIRRGVERLVYLPDWLDDPQGRPLSLSLPFTPGNQPHQGAIVADYFDNLLPDSESIRR
RIAQRYRLRSTAPFELLASIGRDCVGAIQMLPPDETPVDLEAIEGAPLDDAAVANVLRHATATPLPGSGEPDGDLRLSIA
GAQEKTALLRQRNRWLRPSGSTPTTHIFKLPLGRVGNMQADMRTSVENEWLCSKLVAAYGLSVAPCEIGRFDDQKALIVE
RFDRRPSRDGSWILRLPQEDMCQATGTPSGAKYETDGGPGIETIMGILANSADASRDRMNFFVAQLVFWVLAAIDGHAKN
FSIAHLPGNAYRSTPLYDVLSAHPIIGTRRNQIPPRRARLAMAVCGKNRHYVIGEIQPRHWIAQGRRVGLTEDDVRAAMA
AVSARTEPAIAEAAAQIPPDFPADVADAIFAGMRRQSRKLAAADPA

Download         Length: 1341 bp

>T75939 NZ_CP021067:c870144-868804 [Burkholderia cenocepacia]
ATGGTCGCACGCGCCCGCAGCGACCGGCTCGACCTGTGGATGAACGGCATTCCTGTCGGCTACTGGGAAATCCGGCGCGG
GGTCGAGCGTCTCGTCTACCTGCCGGACTGGCTCGATGATCCCCAGGGCCGACCACTGTCATTGTCGCTCCCCTTCACGC
CCGGCAACCAGCCGCACCAGGGTGCGATCGTGGCCGACTACTTCGACAACCTGCTGCCGGACAGCGAGTCGATCCGTCGC
CGCATCGCGCAGCGTTACCGGCTCCGATCGACAGCGCCGTTCGAATTGCTCGCGTCGATCGGCCGCGATTGCGTCGGCGC
GATCCAAATGCTGCCGCCCGACGAGACCCCGGTCGATCTCGAGGCAATCGAAGGCGCGCCGCTCGACGACGCAGCCGTTG
CCAATGTGCTGCGCCACGCGACCGCCACGCCACTGCCCGGCAGCGGAGAACCGGACGGCGACCTGCGCCTGTCGATTGCC
GGCGCGCAGGAAAAGACCGCGCTGCTGCGTCAGCGCAACCGCTGGCTGCGGCCGTCGGGCAGCACGCCGACGACCCACAT
CTTCAAGCTGCCGCTCGGGCGCGTCGGCAACATGCAGGCCGACATGCGCACGTCCGTCGAAAACGAATGGTTGTGCTCGA
AGCTCGTCGCCGCGTACGGCCTGTCGGTCGCGCCGTGCGAAATCGGCCGGTTCGACGATCAGAAGGCACTCATCGTCGAG
CGCTTCGACCGTCGCCCGTCGCGCGACGGCTCGTGGATCCTGCGGCTGCCGCAGGAGGACATGTGTCAGGCGACCGGCAC
GCCGTCGGGGGCGAAATACGAAACGGACGGCGGCCCCGGCATCGAGACGATCATGGGCATCCTCGCGAATTCGGCCGACG
CTTCGCGCGACCGGATGAATTTCTTTGTCGCACAGCTTGTATTCTGGGTGTTGGCGGCGATCGACGGCCACGCGAAGAAC
TTCAGCATCGCGCACCTGCCCGGTAATGCGTATCGCAGCACGCCGCTGTACGACGTGCTGTCCGCGCATCCGATCATCGG
TACGCGCCGCAACCAGATTCCGCCGCGCCGCGCCCGCCTGGCGATGGCCGTCTGCGGGAAGAACCGGCACTACGTGATCG
GTGAAATCCAGCCGCGCCACTGGATCGCACAGGGCCGCCGTGTCGGCCTGACCGAAGACGACGTGCGGGCCGCGATGGCG
GCCGTCTCAGCACGGACGGAGCCCGCGATTGCCGAAGCCGCCGCGCAGATCCCGCCGGACTTTCCCGCGGACGTGGCAGA
CGCGATCTTCGCGGGCATGCGTCGGCAAAGCCGCAAACTCGCGGCGGCCGATCCGGCGTGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14474.65 Da        Isoelectric Point: 11.9664

>AT75939 WP_023477872.1 NZ_CP021067:c870554-870147 [Burkholderia cenocepacia]
MAFPVQTLTQLRPILVGFRKSAGLTQAQLAARLGITQQSYAQLEANPSAVSIERLFKVMNALGVRMTLSLDERDAPAEAA
DSASVAEPVARRKPVASKRGTTAAKTLTGTAVGAARRRPTATTRTTPRVSKREDW

Download         Length: 408 bp

>AT75939 NZ_CP021067:c870554-870147 [Burkholderia cenocepacia]
ATGGCCTTTCCTGTCCAGACCCTGACCCAGTTGCGTCCGATCCTCGTCGGCTTCCGCAAATCCGCGGGGCTCACGCAGGC
GCAACTGGCCGCTCGCCTCGGCATCACCCAGCAATCTTATGCTCAGCTCGAAGCCAACCCGTCGGCGGTCAGCATCGAAC
GGCTTTTCAAGGTGATGAACGCGCTTGGCGTTCGCATGACGCTCAGCCTCGACGAGCGGGATGCACCGGCGGAAGCGGCC
GATTCGGCTTCCGTTGCCGAACCGGTGGCGCGCCGCAAGCCGGTCGCGAGCAAGCGCGGCACCACGGCCGCCAAAACCCT
GACCGGCACCGCCGTCGGCGCGGCGAGGAGGCGCCCGACAGCGACGACTCGGACCACGCCACGCGTCTCGAAGCGGGAGG
ACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G6V4I5

Antitoxin

Source ID Structure

References