Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 863643..864276 Replicon chromosome
Accession NZ_CP021067
Organism Burkholderia cenocepacia strain PC184 Mulks

Toxin (Protein)


Gene name vapC Uniprot ID A0A3N9EG56
Locus tag B9Z07_RS03935 Protein ID WP_023477876.1
Coordinates 863863..864276 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A807EDB2
Locus tag B9Z07_RS03930 Protein ID WP_027808267.1
Coordinates 863643..863876 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B9Z07_RS03915 858701..860395 + 1695 WP_006479033.1 VRR-NUC domain-containing protein -
B9Z07_RS03920 860392..862692 + 2301 WP_034174802.1 ATP-dependent DNA helicase -
B9Z07_RS03925 862708..863481 - 774 WP_006479031.1 helix-turn-helix domain-containing protein -
B9Z07_RS03930 863643..863876 + 234 WP_027808267.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
B9Z07_RS03935 863863..864276 + 414 WP_023477876.1 PIN domain-containing protein Toxin
B9Z07_RS03940 864349..865650 - 1302 WP_034174801.1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase -
B9Z07_RS03945 865855..867162 - 1308 WP_011547704.1 shikimate transporter -
B9Z07_RS03955 867520..868647 + 1128 WP_011547703.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(10-119)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15637.91 Da        Isoelectric Point: 5.6324

>T75938 WP_023477876.1 NZ_CP021067:863863-864276 [Burkholderia cenocepacia]
MSRIETEKSFVDSNVVLYLLSEDETKANRAESLFLRRPTISVQVLNEVASVCNRKLRMPWREVGKFLEPIRSLCHVVPLT
VDAHDLARRLAEWHRLSFYDACIVATASIEGCEYLYTEDMHDGLQVDGGPVLRNPFA

Download         Length: 414 bp

>T75938 NZ_CP021067:863863-864276 [Burkholderia cenocepacia]
ATGAGCAGGATTGAGACGGAGAAATCATTCGTCGACAGCAATGTCGTGCTGTATCTGCTGTCCGAGGACGAAACCAAGGC
AAACCGTGCGGAGTCGCTGTTCCTGCGGCGGCCGACCATCAGCGTCCAGGTACTGAACGAAGTCGCCAGTGTGTGCAACC
GCAAATTGCGGATGCCGTGGCGCGAGGTAGGGAAGTTTTTGGAGCCGATCAGGAGTTTGTGCCATGTCGTACCGCTCACC
GTCGATGCGCACGACCTCGCGCGGCGGCTGGCAGAGTGGCATCGCTTGTCCTTCTACGATGCATGCATCGTGGCAACTGC
CTCAATCGAAGGATGTGAATACCTGTACACCGAAGACATGCACGACGGCTTGCAAGTGGACGGCGGTCCGGTATTGCGAA
ATCCGTTTGCCTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8807.99 Da        Isoelectric Point: 5.1468

>AT75938 WP_027808267.1 NZ_CP021067:863643-863876 [Burkholderia cenocepacia]
MQVAKWGNSLAVRLPASVVDALELREGDDIEIVVDSPRVFAVSRKPRPDELLERLRRFRGKLPADFKFSRDDANEQD

Download         Length: 234 bp

>AT75938 NZ_CP021067:863643-863876 [Burkholderia cenocepacia]
ATGCAGGTCGCAAAATGGGGCAATAGCCTGGCGGTTCGCCTTCCGGCCAGTGTGGTTGACGCACTGGAACTCCGCGAAGG
CGACGATATTGAGATAGTGGTCGACAGCCCGCGGGTTTTCGCGGTAAGTCGCAAGCCGAGGCCCGACGAGCTTCTGGAGC
GACTGCGGCGTTTCAGGGGCAAATTGCCCGCCGATTTCAAGTTCAGCCGGGACGATGCGAATGAGCAGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3N9EG56

Antitoxin

Source ID Structure
AlphaFold DB A0A807EDB2

References