Detailed information of TA system TA075937

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 279533..280174
• Replicon: chromosome
• Accession: NZ_CP021067
• Organism: Burkholderia cenocepacia strain PC184 Mulks

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B1K4X0
• Locus tag: B9Z07_RS01285
• Protein ID: WP_006479524.1
• Coordinates: 279836..280174 (-)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: B9Z07_RS01280
• Protein ID: WP_006479525.1
• Coordinates: 279533..279832 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B9Z07_RS01255	274712..275983	+	1272	WP_034174903.1	Rieske 2Fe-2S domain-containing protein	-
B9Z07_RS01260	275998..276474	+	477	WP_006479528.1	aromatic-ring-hydroxylating dioxygenase subunit beta	-
B9Z07_RS01265	276510..276836	+	327	WP_006479527.1	non-heme iron oxygenase ferredoxin subunit	-
B9Z07_RS01270	276826..278046	+	1221	WP_105797742.1	FAD-dependent oxidoreductase	-
B9Z07_RS01275	278198..279484	+	1287	WP_034174902.1	DUF445 domain-containing protein	-
B9Z07_RS01280	279533..279832	-	300	WP_006479525.1	putative addiction module antidote protein	Antitoxin
B9Z07_RS01285	279836..280174	-	339	WP_006479524.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
B9Z07_RS01295	280553..282193	+	1641	WP_006479523.1	acetolactate synthase large subunit	-
B9Z07_RS01300	282222..283655	+	1434	WP_006479522.1	aldehyde dehydrogenase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (26-98)

Antitoxin

• Uncharacterized protein HI1420 (4-96)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12604.47 Da
• Isoelectric Point: 8.9594

>T75937 WP_006479524.1 NZ_CP021067:c280174-279836 [Burkholderia cenocepacia]
MVDILQSVPYSAPTFSIRTTDVFEAWFAGLPDRVARRRIQARIDRLSMGNPGDWKSAGSPVVEMRIDHGPGYRVYYVRRG
TIWVILLCGGDKSTQQADIRAAHAMLAHLDME

Nucleotide

• Length: 339 bp

>T75937 NZ_CP021067:c280174-279836 [Burkholderia cenocepacia]
ATGGTTGACATCCTGCAATCCGTGCCCTACAGTGCGCCTACGTTCAGCATCCGGACCACCGACGTCTTCGAAGCGTGGTT
CGCCGGCCTGCCGGATCGCGTCGCGCGGCGGCGCATCCAGGCGCGCATCGACCGTCTGTCGATGGGCAATCCGGGCGACT
GGAAATCCGCCGGCTCCCCCGTCGTCGAAATGCGTATCGACCACGGCCCCGGCTATCGCGTCTATTACGTGAGGCGCGGA
ACGATATGGGTCATCCTGCTCTGCGGCGGCGATAAGTCGACGCAACAGGCCGACATCCGCGCCGCGCACGCAATGCTCGC
GCACCTCGACATGGAGTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10636.06 Da
• Isoelectric Point: 6.4772

>AT75937 WP_006479525.1 NZ_CP021067:c279832-279533 [Burkholderia cenocepacia]
MDKIKTRPWDSAEHLKTEDDMADYFDACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGARAAA

Nucleotide

• Length: 300 bp

>AT75937 NZ_CP021067:c279832-279533 [Burkholderia cenocepacia]
ATGGACAAGATCAAGACGCGGCCGTGGGATTCGGCCGAACACCTGAAAACCGAAGACGACATGGCCGACTACTTCGACGC
CTGCCTGCAGGAGGCCGGCGACGATCCGGCCTTCATCGCGCATGCGCTCGGCGTGATCGCCCGTGCCCGCGGCATGTCGC
AGGTCGCACGCGATGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATCCTGAAGGTCATCAAGGCGCTCGGCCTGCAATTGCACGGCGCCAGGGCTGCCGCATGA

Structures

Toxin

• AlphaFold DB: B1K4X0