Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2036817..2037308 Replicon chromosome
Accession NZ_CP021059
Organism Macrococcus canis strain KM 45013

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MCCS_RS10845 Protein ID WP_086043355.1
Coordinates 2036817..2037167 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MCCS_RS12505 Protein ID WP_101495293.1
Coordinates 2037168..2037308 (-) Length 47 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MCCS_RS10820 2031925..2034060 - 2136 WP_086043350.1 RNA-binding transcriptional accessory protein -
MCCS_RS10825 2034137..2034904 - 768 WP_086043351.1 RNA polymerase sigma factor SigB -
MCCS_RS10830 2034909..2035352 - 444 WP_086043352.1 anti-sigma B factor RsbW -
MCCS_RS10835 2035357..2035680 - 324 WP_086043353.1 anti-sigma factor antagonist -
MCCS_RS10840 2035761..2036768 - 1008 WP_086043354.1 PP2C family protein-serine/threonine phosphatase -
MCCS_RS10845 2036817..2037167 - 351 WP_086043355.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MCCS_RS12505 2037168..2037308 - 141 WP_101495293.1 antitoxin MazE Antitoxin
MCCS_RS10850 2037370..2038512 - 1143 WP_086043356.1 alanine racemase -
MCCS_RS10855 2038538..2038894 - 357 WP_086043357.1 holo-ACP synthase -
MCCS_RS10860 2038836..2039357 - 522 WP_086043358.1 PH domain-containing protein -
MCCS_RS10865 2039341..2040852 - 1512 WP_086043359.1 PH domain-containing protein -
MCCS_RS10870 2040842..2041318 - 477 WP_086043360.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12705.88 Da        Isoelectric Point: 9.9423

>T75934 WP_086043355.1 NZ_CP021059:c2037167-2036817 [Macrococcus canis]
MKRGDVYLADLSPVKGSEQGGKRPVVIIQNNIGNKHSPTVIVAAITAKINKAKIPTHVEIGKTTHHLEKDSVILLEQIRT
IDKNRLIDHLTVLDKAKMKEVDVALLISLGLSIDSE

Download         Length: 351 bp

>T75934 NZ_CP021059:c2037167-2036817 [Macrococcus canis]
ATGAAACGTGGAGATGTTTATTTAGCTGATCTGTCACCAGTGAAGGGGTCTGAACAAGGCGGTAAACGCCCCGTCGTTAT
TATTCAGAATAATATTGGGAATAAACATAGTCCTACAGTGATTGTAGCCGCAATTACAGCAAAGATTAATAAGGCAAAGA
TCCCCACCCATGTGGAAATTGGCAAGACCACGCATCACCTGGAAAAGGATTCGGTAATATTGCTTGAACAAATTAGAACT
ATTGATAAGAATAGGTTAATTGATCATCTGACAGTGCTTGATAAGGCAAAGATGAAAGAAGTGGATGTGGCACTTTTAAT
TAGTTTAGGGTTATCAATCGATAGTGAATAG

Antitoxin


Download         Length: 47 a.a.        Molecular weight: 5319.89 Da        Isoelectric Point: 3.8301

>AT75934 WP_101495293.1 NZ_CP021059:c2037308-2037168 [Macrococcus canis]
MSQKLEQMLIEGYQSMAEINLSIASEHYILECEVNDNHQTYTLDGE

Download         Length: 141 bp

>AT75934 NZ_CP021059:c2037308-2037168 [Macrococcus canis]
ATGAGCCAGAAGCTGGAGCAAATGCTGATAGAAGGATATCAATCAATGGCAGAGATTAATTTATCGATAGCATCAGAACA
TTATATATTAGAATGTGAAGTTAATGATAACCATCAGACATATACCCTTGATGGTGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References