Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1160914..1161401 Replicon chromosome
Accession NZ_CP021059
Organism Macrococcus canis strain KM 45013

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MCCS_RS05890 Protein ID WP_086042498.1
Coordinates 1161135..1161401 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MCCS_RS05885 Protein ID WP_086042497.1
Coordinates 1160914..1161138 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MCCS_RS05840 1156476..1156934 + 459 WP_086042488.1 NUDIX domain-containing protein -
MCCS_RS05845 1157030..1157281 + 252 WP_086042489.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MCCS_RS05850 1157281..1157541 + 261 WP_086042490.1 Txe/YoeB family addiction module toxin -
MCCS_RS05855 1157542..1157991 - 450 WP_086042491.1 GNAT family N-acetyltransferase -
MCCS_RS05860 1158209..1159099 + 891 WP_086042492.1 phosphotransferase -
MCCS_RS05865 1159131..1159313 + 183 WP_086042493.1 hypothetical protein -
MCCS_RS05870 1159319..1160080 + 762 WP_086042494.1 hypothetical protein -
MCCS_RS05875 1160103..1160375 - 273 WP_086042495.1 Txe/YoeB family addiction module toxin -
MCCS_RS05880 1160368..1160625 - 258 WP_086042496.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MCCS_RS05885 1160914..1161138 + 225 WP_086042497.1 toxin-antitoxin system, antitoxin component Antitoxin
MCCS_RS05890 1161135..1161401 + 267 WP_086042498.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MCCS_RS05895 1161512..1161880 + 369 WP_086042499.1 GntR family transcriptional regulator -
MCCS_RS05900 1161880..1162980 + 1101 WP_086042500.1 DUF1648 domain-containing protein -
MCCS_RS05905 1163461..1164723 + 1263 WP_086042501.1 Y-family DNA polymerase -
MCCS_RS05910 1164876..1165064 + 189 WP_086042502.1 hypothetical protein -
MCCS_RS05915 1165197..1166237 + 1041 WP_086042503.1 M42 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10483.30 Da        Isoelectric Point: 10.5488

>T75933 WP_086042498.1 NZ_CP021059:1161135-1161401 [Macrococcus canis]
MKYSVEYVPKVIKQLRKMDAQSSRLLLQWINKNIVHCEDPRSSGKALTGNYSGFWRYRVGQFRIITKIEDDKLIILVISI
DHRKNIYR

Download         Length: 267 bp

>T75933 NZ_CP021059:1161135-1161401 [Macrococcus canis]
ATGAAATACAGTGTCGAATATGTTCCTAAGGTCATTAAACAATTACGAAAAATGGATGCCCAATCCAGTAGATTACTATT
ACAATGGATTAATAAAAATATTGTTCATTGTGAAGATCCCAGAAGCTCAGGAAAAGCTTTGACTGGTAACTATAGTGGTT
TTTGGCGTTATAGAGTTGGACAATTTCGTATTATTACTAAAATAGAAGATGATAAATTAATTATTTTAGTAATTTCAATA
GATCATAGAAAAAATATTTATCGATAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8722.87 Da        Isoelectric Point: 4.2805

>AT75933 WP_086042497.1 NZ_CP021059:1160914-1161138 [Macrococcus canis]
MATITIRVSEDEKNFLKYMSEFMNLSLTDLIKNYTIEDLEDLFDTHVADKAYIEWSKNKQTVSHNDVMQEFGLL

Download         Length: 225 bp

>AT75933 NZ_CP021059:1160914-1161138 [Macrococcus canis]
ATGGCTACTATTACTATCAGGGTAAGCGAAGATGAAAAGAATTTTTTAAAATATATGTCAGAATTTATGAACTTAAGCTT
AACTGACTTAATTAAGAATTATACCATTGAAGATCTTGAAGATTTATTTGATACTCATGTTGCCGATAAGGCATATATTG
AATGGTCTAAAAATAAGCAGACTGTTTCTCACAATGATGTTATGCAAGAATTTGGATTACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References