Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2028655..2029146 Replicon chromosome
Accession NZ_CP021058
Organism Macrococcus caseolyticus strain IMD0819

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag CA207_RS10720 Protein ID WP_086039219.1
Coordinates 2028655..2029005 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag CA207_RS12250 Protein ID WP_101031708.1
Coordinates 2029006..2029146 (-) Length 47 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA207_RS10695 2023759..2025894 - 2136 WP_086039217.1 RNA-binding transcriptional accessory protein -
CA207_RS10700 2025971..2026738 - 768 WP_015912228.1 RNA polymerase sigma factor SigB -
CA207_RS10705 2026743..2027186 - 444 WP_015912229.1 anti-sigma B factor RsbW -
CA207_RS10710 2027191..2027514 - 324 WP_015912230.1 anti-sigma factor antagonist -
CA207_RS10715 2027599..2028606 - 1008 WP_086039218.1 PP2C family protein-serine/threonine phosphatase -
CA207_RS10720 2028655..2029005 - 351 WP_086039219.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CA207_RS12250 2029006..2029146 - 141 WP_101031708.1 antitoxin MazE Antitoxin
CA207_RS10725 2029207..2030349 - 1143 WP_086039220.1 alanine racemase -
CA207_RS10730 2030375..2030731 - 357 WP_086039221.1 holo-ACP synthase -
CA207_RS10735 2030673..2031194 - 522 WP_015912235.1 PH domain-containing protein -
CA207_RS10740 2031178..2032689 - 1512 WP_086039222.1 PH domain-containing protein -
CA207_RS10745 2032679..2033155 - 477 WP_041636191.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12706.90 Da        Isoelectric Point: 10.1643

>T75930 WP_086039219.1 NZ_CP021058:c2029005-2028655 [Macrococcus caseolyticus]
MKRGDVFLADLSPVKGSEQGGKRPVVIIQNNIGNKYSPTVIVAAITAKINKAKIPTHVEIGKATHRLEKDSVILLEQIRT
IDKNRLIDHLTVLDKAKMKEVDTALIISLGLSIDSE

Download         Length: 351 bp

>T75930 NZ_CP021058:c2029005-2028655 [Macrococcus caseolyticus]
ATGAAACGCGGAGATGTTTTTTTGGCTGATCTGTCACCAGTGAAGGGATCTGAACAAGGCGGTAAACGCCCCGTCGTTAT
TATTCAGAATAATATAGGGAATAAATATAGTCCCACTGTGATTGTAGCGGCAATTACTGCAAAGATTAATAAGGCAAAAA
TCCCCACCCATGTTGAAATTGGCAAGGCAACGCATCGCTTAGAAAAGGATTCGGTAATACTGCTGGAACAAATTAGAACC
ATTGATAAGAATAGGTTGATTGATCATTTAACTGTGCTTGATAAGGCGAAGATGAAAGAAGTGGATACTGCACTTATAAT
TAGTTTAGGTTTATCAATCGATAGTGAATAG

Antitoxin


Download         Length: 47 a.a.        Molecular weight: 5326.88 Da        Isoelectric Point: 3.8301

>AT75930 WP_101031708.1 NZ_CP021058:c2029146-2029006 [Macrococcus caseolyticus]
MSQKLEQMLIEGYQSMAEINLSIASEHYVLECEVTDNHQTYTFDGE

Download         Length: 141 bp

>AT75930 NZ_CP021058:c2029146-2029006 [Macrococcus caseolyticus]
ATGAGCCAGAAGCTAGAACAAATGCTGATAGAAGGTTATCAATCAATGGCAGAGATAAATTTATCGATAGCATCAGAGCA
TTATGTATTAGAATGCGAAGTTACTGATAACCATCAGACATATACCTTTGATGGTGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References