Detailed information of TA system TA075928

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 4706823..4707514
• Replicon: chromosome
• Accession: NZ_CP021056
• Organism: Richelia sinica FACHB-800 strain FACHB 800

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: B6N60_RS24325
• Protein ID: WP_244997518.1
• Coordinates: 4706823..4707032 (+)
• Length: 70 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: B6N60_RS19855
• Protein ID: WP_190370542.1
• Coordinates: 4707176..4707514 (+)
• Length: 113 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B6N60_RS19850 (B6N60_04379)	4702528..4706514	+	3987	WP_190605243.1	magnesium chelatase subunit H	-
B6N60_RS24325	4706823..4707032	+	210	WP_244997518.1	type II toxin-antitoxin system HicA family toxin	Toxin
B6N60_RS19855 (B6N60_04381)	4707176..4707514	+	339	WP_190370542.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
B6N60_RS19860 (B6N60_04382)	4707523..4708098	+	576	WP_190605241.1	Uma2 family endonuclease	-
B6N60_RS19865 (B6N60_04383)	4708172..4708525	+	354	WP_190605239.1	hypothetical protein	-
B6N60_RS19870 (B6N60_04384)	4708577..4709587	+	1011	WP_190605237.1	DUF4238 domain-containing protein	-
B6N60_RS24645 (B6N60_04385)	4709645..4709773	+	129	WP_256443773.1	hypothetical protein	-
B6N60_RS19875 (B6N60_04386)	4709801..4710067	+	267	WP_190605235.1	type II toxin-antitoxin system HicA family toxin	-
B6N60_RS19880 (B6N60_04387)	4710051..4710263	+	213	WP_190605233.1	type II toxin-antitoxin system HicB family antitoxin	-
B6N60_RS19885 (B6N60_04388)	4710371..4710769	-	399	WP_190605231.1	PIN domain-containing protein	-
B6N60_RS19890 (B6N60_04389)	4710776..4711009	-	234	WP_190605228.1	hypothetical protein	-
B6N60_RS19895	4711199..4711408	-	210	WP_190605226.1	hypothetical protein	-
B6N60_RS19900 (B6N60_04392)	4711392..4711592	-	201	WP_039203742.1	hypothetical protein	-
B6N60_RS19905 (B6N60_04393)	4711589..4711834	-	246	WP_217312828.1	type II toxin-antitoxin system RelE/ParE family toxin	-
B6N60_RS19910	4711840..4712082	-	243	WP_190605224.1	type II toxin-antitoxin system ParD family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Uncharacterised protein family HicB (52-102)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7724.80 Da
• Isoelectric Point: 7.3179

>T75928 WP_244997518.1 NZ_CP021056:4706823-4707032 [Richelia sinica FACHB-800]
IALNNKQRKTLELIFTNPVPANIIWQDIESLFIALGAYISQGSGSRVGVKLNDVKGHFHEPHPEKETDK

Nucleotide

• Length: 210 bp

>T75928 NZ_CP021056:4706823-4707032 [Richelia sinica FACHB-800]
ATAGCTCTTAATAATAAACAAAGAAAAACTTTAGAATTAATTTTTACAAATCCTGTACCAGCAAATATTATTTGGCAAGA
TATTGAAAGTTTATTTATAGCTTTAGGTGCTTATATTAGTCAAGGTAGCGGTTCAAGAGTAGGAGTTAAATTAAATGATG
TTAAAGGTCATTTTCATGAACCACATCCAGAAAAAGAAACCGATAAATGA

Antitoxin

Protein

• Length: 113 a.a.
• Molecular weight: 12539.36 Da
• Isoelectric Point: 5.2342

>AT75928 WP_190370542.1 NZ_CP021056:4707176-4707514 [Richelia sinica FACHB-800]
MLTYKGYTASIEVDVEAGILFGRVLDINDVITFKAKTVEEARQEFQTSIDGYLAFCEELGEEPDKPFSGKLPFRTTPEHH
RKIFIAAKKAGKSINAWMDEILINAAEKSVKA

Nucleotide

• Length: 339 bp

>AT75928 NZ_CP021056:4707176-4707514 [Richelia sinica FACHB-800]
ATGTTGACTTATAAAGGATACACAGCATCAATTGAAGTAGATGTAGAAGCAGGAATACTTTTCGGTCGTGTTCTTGATAT
TAATGATGTAATTACTTTTAAAGCGAAAACGGTAGAAGAAGCACGTCAAGAATTTCAGACTTCTATTGATGGTTATTTAG
CTTTTTGTGAAGAATTAGGCGAAGAACCGGATAAACCTTTTTCCGGGAAACTACCGTTTCGTACAACTCCAGAACATCAT
CGTAAAATTTTTATTGCAGCTAAAAAAGCTGGAAAAAGTATCAATGCTTGGATGGATGAAATTTTAATCAATGCTGCTGA
AAAATCAGTCAAAGCATAG