Detailed information of TA system TA075900

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 11629..12296
• Replicon: plasmid pA
• Accession: NZ_CP021019
• Organism: Xanthomonas citri pv. phaseoli var. fuscans strain CFBP6167

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A3T0G501
• Locus tag: XcfCFBP6167P_RS23245
• Protein ID: WP_022557732.1
• Coordinates: 11629..12045 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: U4M4Z6
• Locus tag: XcfCFBP6167P_RS23250
• Protein ID: WP_022557731.1
• Coordinates: 12042..12296 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XcfCFBP6167P_RS23220	7359..8678	+	1320	WP_022557736.1	DUF4990 domain-containing protein	-
XcfCFBP6167P_RS23225	8805..10097	+	1293	WP_033481893.1	hypothetical protein	-
XcfCFBP6167P_RS23230	10249..10779	+	531	Protein_12	DNA topoisomerase III	-
XcfCFBP6167P_RS23235	10849..10986	+	138	Protein_13	transposase	-
XcfCFBP6167P_RS23240	11061..11615	-	555	WP_033482006.1	plasmid pRiA4b ORF-3 family protein	-
XcfCFBP6167P_RS23245	11629..12045	-	417	WP_022557732.1	type II toxin-antitoxin system VapC family toxin	Toxin
XcfCFBP6167P_RS23250	12042..12296	-	255	WP_022557731.1	plasmid stability protein	Antitoxin
XcfCFBP6167P_RS23255	12508..12753	+	246	Protein_17	recombinase family protein	-
XcfCFBP6167P_RS23260	12790..14016	-	1227	WP_011345585.1	IS256-like element ISXax1 family transposase	-
XcfCFBP6167P_RS23265	14150..15202	-	1053	WP_022557730.1	type III secretion system YopJ family effector AvrBsT	-
XcfCFBP6167P_RS25370	15337..15441	-	105	Protein_20	type III secretion system effector protein	-
XcfCFBP6167P_RS23275	16123..17037	+	915	WP_022557729.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..62464	62464
	-	inside	IScluster/Tn	-	-	10849..14016	3167

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 14833.04 Da
• Isoelectric Point: 4.6812

>T75900 WP_022557732.1 NZ_CP021019:c12045-11629 [Xanthomonas citri pv. phaseoli var. fuscans]
MIVLDTNVVSEAMKPEPHPSVRTWLNDQAAETLYLSSVTLAELLFGIAALPAGKRKDMLEQALDGLMGLFRDRVLPFDID
AARRYAELAVTAKIGGRGFPTPDGYIAAIAASRGFIVASRDTAPYEAAGVTVINPWEG

Nucleotide

• Length: 417 bp

>T75900 NZ_CP021019:c12045-11629 [Xanthomonas citri pv. phaseoli var. fuscans]
ATGATCGTTCTCGATACCAACGTCGTTTCCGAGGCGATGAAGCCCGAGCCGCACCCATCCGTGCGGACCTGGTTGAACGA
TCAAGCCGCTGAAACACTGTACCTGTCCAGCGTGACGCTGGCCGAACTGCTATTTGGCATCGCTGCGCTTCCTGCCGGTA
AGCGCAAGGACATGCTGGAACAGGCCCTTGATGGCCTCATGGGCCTGTTTAGGGATCGGGTGTTGCCATTCGACATCGAT
GCAGCGCGGCGTTATGCCGAATTGGCCGTGACGGCAAAGATCGGAGGGCGAGGATTTCCGACACCCGACGGCTACATCGC
AGCGATTGCTGCCTCGCGGGGTTTCATTGTGGCGTCACGCGACACGGCCCCTTACGAAGCGGCCGGCGTAACCGTCATCA
ATCCGTGGGAAGGGTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9388.80 Da
• Isoelectric Point: 8.9326

>AT75900 WP_022557731.1 NZ_CP021019:c12296-12042 [Xanthomonas citri pv. phaseoli var. fuscans]
MAMLTVRNLPDDVHRALRMRAAQNGHSTEAEVREILATAVKPETRVRLGEALAALGRKIGLTNEDFEVFDRVRDKTPAVP
PRLE

Nucleotide

• Length: 255 bp

>AT75900 NZ_CP021019:c12296-12042 [Xanthomonas citri pv. phaseoli var. fuscans]
ATGGCAATGCTGACAGTACGTAATCTGCCGGATGATGTGCACCGCGCATTGCGCATGCGGGCCGCTCAAAATGGGCACAG
CACCGAGGCCGAGGTCCGCGAGATTCTGGCGACCGCAGTCAAGCCAGAGACGCGCGTTCGCCTAGGCGAAGCCTTGGCGG
CTTTGGGTCGCAAGATTGGCCTGACGAATGAGGACTTCGAGGTCTTCGATCGGGTAAGAGACAAGACGCCGGCCGTCCCG
CCGAGGCTTGAATGA

Structures

Toxin

• AlphaFold DB: A0A3T0G501

Antitoxin

• AlphaFold DB: A0A3T0G545