Detailed information of TA system TA075881

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 25712..26379
• Replicon: plasmid pA
• Accession: NZ_CP021002
• Organism: Xanthomonas citri pv. phaseoli var. fuscans strain CFBP6166

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A3T0G501
• Locus tag: XcfCFBP6166P_RS22660
• Protein ID: WP_022557732.1
• Coordinates: 25712..26128 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: U4M4Z6
• Locus tag: XcfCFBP6166P_RS22665
• Protein ID: WP_022557731.1
• Coordinates: 26125..26379 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XcfCFBP6166P_RS22635	21442..22761	+	1320	WP_022557736.1	DUF4990 domain-containing protein	-
XcfCFBP6166P_RS22640	22888..24180	+	1293	WP_033481893.1	hypothetical protein	-
XcfCFBP6166P_RS22645	24332..24862	+	531	Protein_27	DNA topoisomerase III	-
XcfCFBP6166P_RS22650	24932..25069	+	138	Protein_28	transposase	-
XcfCFBP6166P_RS22655	25144..25698	-	555	WP_033482006.1	plasmid pRiA4b ORF-3 family protein	-
XcfCFBP6166P_RS22660	25712..26128	-	417	WP_022557732.1	type II toxin-antitoxin system VapC family toxin	Toxin
XcfCFBP6166P_RS22665	26125..26379	-	255	WP_022557731.1	plasmid stability protein	Antitoxin
XcfCFBP6166P_RS22670	26591..26836	+	246	Protein_32	recombinase family protein	-
XcfCFBP6166P_RS22675	26873..28099	-	1227	WP_011345585.1	IS256-like element ISXax1 family transposase	-
XcfCFBP6166P_RS22680	28233..29285	-	1053	WP_022557730.1	type III secretion system YopJ family effector AvrBsT	-
XcfCFBP6166P_RS24160	29420..29524	-	105	Protein_35	type III secretion system effector protein	-
XcfCFBP6166P_RS22690	30207..31121	+	915	WP_022557729.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..53202	53202
	-	inside	IScluster/Tn	-	-	24932..28099	3167

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 14833.04 Da
• Isoelectric Point: 4.6812

>T75881 WP_022557732.1 NZ_CP021002:c26128-25712 [Xanthomonas citri pv. phaseoli var. fuscans]
MIVLDTNVVSEAMKPEPHPSVRTWLNDQAAETLYLSSVTLAELLFGIAALPAGKRKDMLEQALDGLMGLFRDRVLPFDID
AARRYAELAVTAKIGGRGFPTPDGYIAAIAASRGFIVASRDTAPYEAAGVTVINPWEG

Nucleotide

• Length: 417 bp

>T75881 NZ_CP021002:c26128-25712 [Xanthomonas citri pv. phaseoli var. fuscans]
ATGATCGTTCTCGATACCAACGTCGTTTCCGAGGCGATGAAGCCCGAGCCGCACCCATCCGTGCGGACCTGGTTGAACGA
TCAAGCCGCTGAAACACTGTACCTGTCCAGCGTGACGCTGGCCGAACTGCTATTTGGCATCGCTGCGCTTCCTGCCGGTA
AGCGCAAGGACATGCTGGAACAGGCCCTTGATGGCCTCATGGGCCTGTTTAGGGATCGGGTGTTGCCATTCGACATCGAT
GCAGCGCGGCGTTATGCCGAATTGGCCGTGACGGCAAAGATCGGAGGGCGAGGATTTCCGACACCCGACGGCTACATCGC
AGCGATTGCTGCCTCGCGGGGTTTCATTGTGGCGTCACGCGACACGGCCCCTTACGAAGCGGCCGGCGTAACCGTCATCA
ATCCGTGGGAAGGGTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9388.80 Da
• Isoelectric Point: 8.9326

>AT75881 WP_022557731.1 NZ_CP021002:c26379-26125 [Xanthomonas citri pv. phaseoli var. fuscans]
MAMLTVRNLPDDVHRALRMRAAQNGHSTEAEVREILATAVKPETRVRLGEALAALGRKIGLTNEDFEVFDRVRDKTPAVP
PRLE

Nucleotide

• Length: 255 bp

>AT75881 NZ_CP021002:c26379-26125 [Xanthomonas citri pv. phaseoli var. fuscans]
ATGGCAATGCTGACAGTACGTAATCTGCCGGATGATGTGCACCGCGCATTGCGCATGCGGGCCGCTCAAAATGGGCACAG
CACCGAGGCCGAGGTCCGCGAGATTCTGGCGACCGCAGTCAAGCCAGAGACGCGCGTTCGCCTAGGCGAAGCCTTGGCGG
CTTTGGGTCGCAAGATTGGCCTGACGAATGAGGACTTCGAGGTCTTCGATCGGGTAAGAGACAAGACGCCGGCCGTCCCG
CCGAGGCTTGAATGA

Structures

Toxin

• AlphaFold DB: A0A3T0G501

Antitoxin

• AlphaFold DB: A0A3T0G545