Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 42954..43621 Replicon plasmid pA
Accession NZ_CP020986
Organism Xanthomonas citri pv. phaseoli var. fuscans strain CFBP6992

Toxin (Protein)


Gene name vapC Uniprot ID A0A3T0G501
Locus tag XcfCFBP6992P_RS23160 Protein ID WP_022557732.1
Coordinates 43205..43621 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U4M4Z6
Locus tag XcfCFBP6992P_RS23155 Protein ID WP_022557731.1
Coordinates 42954..43208 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XcfCFBP6992P_RS23140 38132..39090 - 959 Protein_40 IS3-like element ISXcd1 family transposase -
XcfCFBP6992P_RS23145 39123..42152 - 3030 WP_022560486.1 Tn3 family transposase -
XcfCFBP6992P_RS23150 42149..42742 - 594 WP_022560487.1 recombinase family protein -
XcfCFBP6992P_RS23155 42954..43208 + 255 WP_022557731.1 plasmid stability protein Antitoxin
XcfCFBP6992P_RS23160 43205..43621 + 417 WP_022557732.1 type II toxin-antitoxin system VapC family toxin Toxin
XcfCFBP6992P_RS23165 43635..44189 + 555 WP_033482006.1 plasmid pRiA4b ORF-3 family protein -
XcfCFBP6992P_RS23170 44264..44401 - 138 Protein_46 transposase -
XcfCFBP6992P_RS23175 44471..45001 - 531 Protein_47 DNA topoisomerase III -
XcfCFBP6992P_RS23180 45153..46445 - 1293 WP_033481893.1 hypothetical protein -
XcfCFBP6992P_RS23185 46572..47891 - 1320 WP_022557736.1 DUF4990 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..67239 67239
- inside IScluster/Tn - - 38132..44401 6269


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14833.04 Da        Isoelectric Point: 4.6812

>T75865 WP_022557732.1 NZ_CP020986:43205-43621 [Xanthomonas citri pv. phaseoli var. fuscans]
MIVLDTNVVSEAMKPEPHPSVRTWLNDQAAETLYLSSVTLAELLFGIAALPAGKRKDMLEQALDGLMGLFRDRVLPFDID
AARRYAELAVTAKIGGRGFPTPDGYIAAIAASRGFIVASRDTAPYEAAGVTVINPWEG

Download         Length: 417 bp

>T75865 NZ_CP020986:43205-43621 [Xanthomonas citri pv. phaseoli var. fuscans]
ATGATCGTTCTCGATACCAACGTCGTTTCCGAGGCGATGAAGCCCGAGCCGCACCCATCCGTGCGGACCTGGTTGAACGA
TCAAGCCGCTGAAACACTGTACCTGTCCAGCGTGACGCTGGCCGAACTGCTATTTGGCATCGCTGCGCTTCCTGCCGGTA
AGCGCAAGGACATGCTGGAACAGGCCCTTGATGGCCTCATGGGCCTGTTTAGGGATCGGGTGTTGCCATTCGACATCGAT
GCAGCGCGGCGTTATGCCGAATTGGCCGTGACGGCAAAGATCGGAGGGCGAGGATTTCCGACACCCGACGGCTACATCGC
AGCGATTGCTGCCTCGCGGGGTTTCATTGTGGCGTCACGCGACACGGCCCCTTACGAAGCGGCCGGCGTAACCGTCATCA
ATCCGTGGGAAGGGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9388.80 Da        Isoelectric Point: 8.9326

>AT75865 WP_022557731.1 NZ_CP020986:42954-43208 [Xanthomonas citri pv. phaseoli var. fuscans]
MAMLTVRNLPDDVHRALRMRAAQNGHSTEAEVREILATAVKPETRVRLGEALAALGRKIGLTNEDFEVFDRVRDKTPAVP
PRLE

Download         Length: 255 bp

>AT75865 NZ_CP020986:42954-43208 [Xanthomonas citri pv. phaseoli var. fuscans]
ATGGCAATGCTGACAGTACGTAATCTGCCGGATGATGTGCACCGCGCATTGCGCATGCGGGCCGCTCAAAATGGGCACAG
CACCGAGGCCGAGGTCCGCGAGATTCTGGCGACCGCAGTCAAGCCAGAGACGCGCGTTCGCCTAGGCGAAGCCTTGGCGG
CTTTGGGTCGCAAGATTGGCCTGACGAATGAGGACTTCGAGGTCTTCGATCGGGTAAGAGACAAGACGCCGGCCGTCCCG
CCGAGGCTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0G501

Antitoxin

Source ID Structure
AlphaFold DB A0A3T0G545

References